Adipogen/Nocodazole/AG-CR1-0019-M050/50 mg
商品编号：
AG-CR1-0019-M050
品牌：
Adipogen Inc
市场价：
¥3400.00
美元价：
2040.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate |
| Product Type | Chemical |
| Properties | |
| Formula | C14H11N3O3S |
| MW | 301.3 |
| CAS | 31430-18-9 |
| RTECS | DD6521000 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or dimethylformamide; almost insoluble in water. |
| Identity | Determined by 1H-NMR. |
| InChi Key | KYRVNWMVYQXFEU-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Microtubule inhibitor [1, 2, 4].
- Antitumor compound [1, 2].
- Mitosis inhibitor [3].
- Arrests the cell cycle at G2/M phase [9].
- Promotes tubulin depolymerization [4].
- Induces fragmentation of the Golgi complex [5].
- Inhibits the T cell antigen receptor [6].
- Stimulates the intrinsic GTPase activity of tubulin [7].
- Activates the JNK/SAPK signaling pathway [8].
- Apoptosis inducer [10, 11].
- Autophagy inhibition through prevention of autophagosome-lysosome fusion.
Product References
- R17934-NSC 238159: a new antitumor drug--I. Effect on experimental tumors and factors influencing effectiveness: G. Atassi and H.J. Tagnon; Eur. J. Cancer 11, 599 (1975)
- R17934-NSC238159: a new antitumor drug--II. Effect on mitotic cycle of L1210 leukemia cells in vivo and synergism with cytosine arabinoside (NSC63878): G. Atassi, et al.; Eur. J. Cancer 11, 609 (1975)
- Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis; M.A. Jordan, et al.; J. Cell Sci. 102, 401 (1992)
- Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro: R.J. Vasquez, et al.; Mol. Biol. Cell 8, 973 (1997)
- Recycling of golgi-resident glycosyltransferases through the ER reveals a novel pathway and provides an explanation for nocodazole-induced Golgi scattering: B. Storrie, et al.; J. Cell Biol. 143, 1505 (1998)
- Nocodazole inhibits signal transduction by the T cell antigen receptor: R.D. Huby, et al.; J. Biol. Chem. 273, 12024 (1998)
- Studies on the nocodazole-induced GTPase activity of tubulin: M.R. Mejillano, et al.; Arch. Biochem. Biophys. 336, 130 (1996)
- Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways: T.H. Wang, et al.; J. Biol. Chem. 273, 4928 (1998)
- Raf-1/MEK/MAPK pathway is necessary for the G2/M transition induced by nocodazole: C. Hayne, et al.; J. Biol. Chem. 275, 31876 (2000)
- Apoptosis induced by microtubule disrupting drugs in normal murine thymocytes in vitro: V. Bumbasirevic, et al.; Scanning Microsc. 9, 509 (1995)
- Nocodazole induces mitotic cell death with apoptotic-like features in Saccharomyces cerevisiae: K. Endo, et al.; FEBS Lett. 584, 2387 (2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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