Adipogen/Nocodazole/AG-CR1-0019-M025/25 mg
商品编号：
AG-CR1-0019-M025
品牌：
Adipogen Inc
市场价：
¥1900.00
美元价：
1140.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate |
| ProductType | Chemical |
| Properties | |
| Formula | C14H11N3O3S |
| MW | 301.3 |
| CAS | 31430-18-9 |
| RTECS | DD6521000 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSOordimethylformamide;almostinsolubleinwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | KYRVNWMVYQXFEU-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Microtubuleinhibitor[1,2,4].
- Antitumorcompound[1,2].
- Mitosisinhibitor[3].
- ArreststhecellcycleatG2/Mphase[9].
- Promotestubulindepolymerization[4].
- InducesfragmentationoftheGolgicomplex[5].
- InhibitstheTcellantigenreceptor[6].
- StimulatestheintrinsicGTPaseactivityoftubulin[7].
- ActivatestheJNK/SAPKsignalingpathway[8].
- Apoptosisinducer[10,11].
- Autophagyinhibitionthroughpreventionofautophagosome-lysosomefusion.
ProductReferences
- R17934-NSC238159:anewantitumordrug--I.Effectonexperimentaltumorsandfactorsinfluencingeffectiveness:G.AtassiandH.J.Tagnon;Eur.J.Cancer11,599(1975)
- R17934-NSC238159:anewantitumordrug--II.EffectonmitoticcycleofL1210leukemiacellsinvivoandsynergismwithcytosinearabinoside(NSC63878):G.Atassi,etal.;Eur.J.Cancer11,609(1975)
- Effectsofvinblastine,podophyllotoxinandnocodazoleonmitoticspindles.Implicationsfortheroleofmicrotubuledynamicsinmitosis;M.A.Jordan,etal.;J.CellSci.102,401(1992)
- Nanomolarconcentrationsofnocodazolealtermicrotubuledynamicinstabilityinvivoandinvitro:R.J.Vasquez,etal.;Mol.Biol.Cell8,973(1997)
- Recyclingofgolgi-residentglycosyltransferasesthroughtheERrevealsanovelpathwayandprovidesanexplanationfornocodazole-inducedGolgiscattering:B.Storrie,etal.;J.CellBiol.143,1505(1998)
- NocodazoleinhibitssignaltransductionbytheTcellantigenreceptor:R.D.Huby,etal.;J.Biol.Chem.273,12024(1998)
- Studiesonthenocodazole-inducedGTPaseactivityoftubulin:M.R.Mejillano,etal.;Arch.Biochem.Biophys.336,130(1996)
- Microtubule-interferingagentsactivatec-JunN-terminalkinase/stress-activatedproteinkinasethroughbothRasandapoptosissignal-regulatingkinasepathways:T.H.Wang,etal.;J.Biol.Chem.273,4928(1998)
- Raf-1/MEK/MAPKpathwayisnecessaryfortheG2/Mtransitioninducedbynocodazole:C.Hayne,etal.;J.Biol.Chem.275,31876(2000)
- Apoptosisinducedbymicrotubuledisruptingdrugsinnormalmurinethymocytesinvitro:V.Bumbasirevic,etal.;ScanningMicrosc.9,509(1995)
- Nocodazoleinducesmitoticcelldeathwithapoptotic-likefeaturesinSaccharomycescerevisiae:K.Endo,etal.;FEBSLett.584,2387(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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