Adipogen/Nigericin . sodium salt/AG-CN2-0020-M025/25 mg
商品编号：
AG-CN2-0020-M025
品牌：
Adipogen Inc
市场价：
¥3000.00
美元价：
1800.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AntibioticK178;HelexinC;PolyetherinA;BRN1696755;AzalomycinM;AntibioticX-464 |
| ProductType | Chemical |
| Properties | |
| Formula | C40H67O11.Na |
| MW | 724.0.23.0 |
| MerckIndex | 14:6541 |
| CAS | 28643-80-3 |
| RTECS | QT6840000 |
| Source/HostChemicals | IsolatedfromStreptomyceshygroscopicus. |
| PurityChemicals | ≥98%(TLC) |
| Appearance | Whitetooff-whitepowder. |
| Solubility | Solubleinmethanol,ethanol,dichlormethaneorethylacetate.Insolubleinwater. |
| InChiKey | MOYOTUKECQMGHE-PDEFJWSRSA-M |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic[1].
- HighaffinityionophoreformonovalentcationssuchasH+,K+,Na+,Pb2+[2,3,4,7,10].
- Showsantibacterial(Gram-positive),antifungal,antitumorandantiviralactivity[3,6].
- Disruptsmembranepotentialofmitochondria[2].
- NLRP3/NALP3activator.Signalsthroughpannexin-1toinducecaspase-1maturationandIL-1βprocessingandrelease[5,8,11,12].
- Autophagymodulator[13]
ProductReferences
- Nigericin,anewcrystallineantibioticfromanunidentifiedstreptomyces:R.L.Harned,etal.;Antibiot.Chemother.1,594(1951)
- PotassiumIon-dependenthydrolysisofadenosinetriphosphateinducedbynigericininmitochondria:S.Estrada-O,etal.;J.Biol.Chem.242,2925(1967)
- Teratogeniceffectsofnigericin,acarboxylicionophore:G.C.Vedel-Macrander&R.D.Hood;Teratology33,47(1986)
- K+/H+-antiporternigericinarrestsDNAsynthesisinEhrlichascitescarcinomacells:L.B.Margolis,etal.;PNAS86,6626(1989)
- IL-1betamaturation:evidencethatmaturecytokineformationcanbeinducedspecificallybynigericin:D.Perregaux,etal.;J.Immunol.149,1294(1992)
- Antitumoreffectofk+/h+-antiporternigericinonhumanlung-carcinomagrowninin-vivo-likehistocultures:B.Baibakov,etal.;Int.J.Oncol.3,1127(1993)
- Nigericin-inducedNa+/H+andK+/H+exchangeinsynaptosomes:effecton[3H]GABArelease:R.Rodríguez&M.Sitges;NeuRochem.Res.21,889(1996)
- Activationofinterleukin-1beta-convertingenzymebynigericinisindependentofapoptosis:N.Watanabe,etal.;Cytokine10,645(1998)
- Nigericininhibitsinsulin-stimulatedglucosetransportin3T3-L1ADIpocytes:C.Y.Chu,etal.;J.CellBiochem.85,83(2002)
- TheionophorenigericintransportsPb2+withhighactivityandselectivity:acomparisontomonensinandionomycin:S.A.Hamidinia,etal.;Biochemistry43,15956(2004)
- CryopyrinactivatestheinflammasomeinresponsetotoxinsandATP:S.Mariathasan,etal.;Nature440,228(2006)
- Pannexin-1couplestomaitotoxin-andnigericin-inducedinterleukin-1betareleasethroughadyeuptake-independentpathway:P.Pelegrin&A.Surprenant;J.Biol.Chem.282,2386(2007)
- Nigericin-inducedimpairmentofautophagicfluxinneuronalcellsisinhibitedbyoverexpressionofBak:J.Lim,etal.;J.Biol.Chem.287,23271(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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