Adipogen/Niclosamide/AG-CR1-3643-M100/100 mg
商品编号：
AG-CR1-3643-M100
品牌：
Adipogen Inc
市场价：
¥700.00
美元价：
420.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide;2′,5-Dichloro-4′-nitro-salicylanilide;BAY-2353;Bayluscid;Cestoid;HL2447;Yomesan |
| ProductType | Chemical |
| Properties | |
| Formula | C13H8Cl2N2O4 |
| MW | 327.1 |
| MerckIndex | 14:6519 |
| CAS | 50-65-7 |
| RTECS | VN8400000 |
| PurityChemicals | ≥95% |
| Appearance | Off-whitetopaleyellowsolid. |
| Solubility | Solublein100%ethanol(5mg/ml)orDMSO(1mg/ml).Insolubleinwater. |
| InChiKey | RJMUSRYZPJIFPJ-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfrommoistureandoxygen. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antihelminthic,molluscicideandtrypanocidalagentthatinhibitsmitochondrialoxidativephosphorylationandanaerobicATPproduction.
- Anticanceragentwithantiproliferativeactivityinabroadspectrumofcancercells.Targetsandinhibitsmultiplesignalingpathways,includingSTAT3,NF-kB,Wnt/β-catenin,NotchandmTORC1.
- ShowntoblockTNF-α-inducedIκBαphosphorylation,translocationofp65andtheexpressionofNF-κB-regulatedgenesandelevatesreactiveoxygenspecies(ROS)levels.
- PromotesFrizzled1internalization,down-regulatestheexpressionofDishevelled-2proteinandinhibitsβ-cateninstabilization.
- InhibitsmTORC1butnotmTORC2signalingincellsmaintainedinnutrient-richconditions.
- CellpermeableselectiveSTAT3inhibitor(IC50=0.25μM).Inhibitstheactivation,nucleartranslocationandtransactivationofSTAT3.SelectiveoverSTAT1,STAT5,JAK1,JAK2andSrckinases.
- Inducescellcyclearrest,growthinhibition,autophagyandapoptosis.
- InhibitsS100A4(Metastasin-1)-inducedmetastasisinvivo.
- Inhibitsandrogenreceptor(AR)splicevariants.
- Anti-inflammatorycompound.
- Quorumsensinginhibitor.
- Broadrangeantiviralagentthattargetsacidifiedendosomes.
- Antiobesityandantidiabeticagent.PositiveallostericneuropetideY4receptorligandandincreasesenergyexpenditureandlipidmetabolismthroughmitochondrialuncoupling.
ProductReferences
- TheeffectofsublethalconcentrationsofthemolluscicideniclosamideontheinfectivityofSchistosomamansonicercariae:A.M.Ghandour&G.Webbe;J.Helminthol.49,245(1975)
- Invitrotrypanocidalactivityoftheanti-helminthicdrugniclosamide:K.Merschjohann&D.Steverding;Exp.Parasitol.118,637(2008)
- Theanti-helminthicniclosamideinhibitsWnt/Frizzled1signaling:M.Chen,etal.;Biochem.48,10267(2009)
- ScreenforchemicalmodulatorsofautophagyrevealsnoveltherapeuticinhibitorsofmTORC1signaling:A.D.Balgi,etal.;PLoSOne4,e7124(2009)
- Identificationofniclosamideasanewsmall-moleculeinhibitoroftheSTAT3signalingpathway:X.Ren,etal.;ACSMed.Chem.Lett.1,454(2010)
- Antineoplasticmechanismsofniclosamideinacutemyelogenousleukemiastemcells:inactivationoftheNF-kappaBpathwayandgenerationofreactiveoxygenspecies:Y.Jin,etal.;CancerRes.70,2516(2010)
- Niclosamide:anestablishedantihelminthicdrugasapotentialtherapyagainstS100A4-mediatedmetastaticcolontumors:D.M.Helfman;J.Natl.CancerInst.103,991(2011)
- Niclosamideinducesmitochondriafragmentationandpromotesbothapoptoticandautophagiccelldeath:S.J.Park,etal.;BMBRep.44,517(2011)
- NiclosamidesuppressescancercellgrowthbyinducingWntco-receptorLRP6degradationandinhibitingtheWnt/β-cateninpathway:W.Lu,etal.;PLoSOne6,e29290(2011)
- Niclosamide,anoldantihelminthicagent,demonstratesantitumoractivitybyblockingmultiplesignalingpathwaysofcancerstemcells:J.X.Pan,etal.;Chin.J.Cancer31,178(2012)(Review)
- Niclosamideisaprotoncarrierandtargetsacidicendosomeswithbroadantiviraleffects:A.Jurgeit,etal.;PLoSPathog.8,e1002976(2012)
- Newlifeforanolddrug:theanthelminticdrugniclosamideinhibitsPseudomonasaeruginosaquorumsensing:F.Imperi,etal.;Antimicrob.AgentsChemother.57,996(2013)
- Theanthelminticdrugniclosamideinducesapoptosis,impairsmetastasisandreducesimmunosuppressivecellsinbreastcancermodel:T.Ye,etal.;PLoSOne9,e85887(2014)
- Multi-targetedtherapyofcancerbyniclosamide:Anewapplicationforanolddrug:Y.Li,etal.;CancerLett.349,8(2014)(Review)
- Niclosamideinhibitsandrogenreceptorvariantsexpressionandovercomesenzalutamideresistanceincastration-resistantprostatecancer:C.Liu,etal.;Clin.CancerRes.20,3198(2014)
- Niclosamideethanolamine-inducedmildmitochondrialuncouplingimprovesdiabeticsymptomsinmice:H.Tao,etal.;Nat.Med.20,1263(2014)
- Niclosamideinhibitstheinflammatoryandangiogenicactivationofhumanumbilicalveinendothelialcells:M.Huang,etal.;Inflamm.Res.64,1023(2015)
- Discoveryofsmall-moleculemodulatorsofthehumanY4receptor:G.Sliwoski,etal.;PLoSOne11,e0157146(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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