Adipogen/Nexturastat A/AG-CR1-3901-M001/1 mg
商品编号：
AG-CR1-3901-M001
品牌：
Adipogen Inc
市场价：
¥2400.00
美元价：
1440.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 4-((1-Butyl-3-phenylureido)methyl)-N-hydroxybenzamide |
| ProductType | Chemical |
| Properties | |
| Formula | C19H23N3O3 |
| MW | 341.4 |
| CAS | 1403783-31-2 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Lightpinksolid. |
| Solubility | SolubleinDMSO.Slightlysolubleinmethanolorethanol(1mg/ml).Almostinsolubleinwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | JZWXMCPARMXZQV-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeable,potentandselectiveclassIIbHDAC6inhibitor(IC50=5.02nM).DisplayshighselectivityoverallotherHDACs(IC50=3-10µM).
- SuppressescellproliferationandpromotesapoptosisinB16cells(GI50=14.3µM)andhumanlymphomacellsHuT-78.Dose-dependentlyinduceshyperacetylationofα-tubulininB16murinemelanomacellswithoutelevatinghistoneH3acetylation.
- InducescellcyclearrestinG1.
- HDAC6deacetylatestubulin,HSP90andthecorehistones(H2A,H2B,H3,H4).Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.HDAC6playsanimportantroleinmicrotubule-dependentcellmotility,transcriptionalregulation,degradationofmisfoldedproteinsandcellcycleandisinvolvedinautophagy,inflammation,cancerandneurodegeneration.
ProductReferences
- Selectivehistonedeacetylase6inhibitorsbearingsubstitutedurealinkersinhibitmelanomacellgrowth:J.A.Bergman,etal.;J.Med.Chem.55,9891(2012)
- Developmentandtherapeuticimplicationsofselectivehistonedeacetylase6inhibitors:J.H.Kalin&J.ABergman;J.Med.Chem.56,6297(2013)
- Targetinghistonedeacetylase6mediatesadualanti-melanomaeffect:Enhancedantitumorimmunityandimpairedcellproliferation:K.V.Woan,etal.;Mol.Oncol.9,1447(2015)
- Trendofhistonedeacetylaseinhibitorsincancertherapy:Isoformselectivityormultitargetedstrategy:L.Zhang,etal.;Med.Res.Rev.35,63(2015)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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