Adipogen/Necrostatin-1/AG-CR1-2900-M005/5 mg
商品编号：
AG-CR1-2900-M005
品牌：
Adipogen Inc
市场价：
¥700.00
美元价：
420.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Nec-1;MTH-Trp;MTH-DL-Tryptophan;Methyl-thiohydantoinDL-tryptophan;5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone |
| ProductType | Chemical |
| Properties | |
| Formula | C13H13N3OS |
| MW | 259.3 |
| CAS | 4311-88-0 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Off-whitetoyellowsolid. |
| Solubility | SolubleinDMSO,ethanolordimethylformamide. |
| OtherProductData | Note:1Necrostatin-1issparinglysolubleinaqueousbuffers.Foramaximumsolubilityinaqueousbuffers,itshouldfirstbedissolvedinDMFandthendilutedwiththeaqueousbufferofchoice.Thesolubilityisapproximately0.5mg/mlina1:1solutionofDMF:PBS(pH7.2)usingthismethod.Werecommendtostoreaqueoussolutionsnotlongerthanoneday. Note:2Insolutiontheproductslightlytautomerizes.Inpolarsolventsthereismoreenolformwhileinnon-polarsolventsthereismoreketoform. |
| InChiKey | TXUWMXQFNYDOEZ-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepunderinertgas. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Stocksolutionsarestableforatleast3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Competitiveindoleamine2,3-dioxygenase(IDO)inhibitor[1,4,9,10].
- Cellpermeable,potentandselectivenecroptosis(anon-apoptoticformofprogrammedcelldeath)inhibitor[2,5].
- Showedneuroprotectioninamurinemodelofischemicbraininjuryinvivo[2,3].
- SelectiveandATP-competitivereceptor-interactingproteinkinase1(RIPK1)inhibitor[6,7].
- UsedininflammatoryanddegenerativediseasemodelstotargetRIPK1[7,9,10].
- Suppressesautophagyandapoptosisinmurinebraininjurymodels[8,9].
- Cardioprotectiveandneuroprotective[11-14].
ProductReferences
- Inhibitionofindoleamine2,3-dioxygenase,animmunoregulatorytargetofthecancersuppressiongeneBin1,potentiatescancerchemotherapy:A.J.Muller,etal.;Nat.Med.11,312(2005)
- Chemicalinhibitorofnonapoptoticcelldeathwiththerapeuticpotentialforischemicbraininjury:A.Degterev,etal.;Nat.Chem.Biol.1,112(2005)
- Necrostatin-1protectsagainstglutamate-inducedglutathionedepletionandcaspase-independentcelldeathinHT-22cells:X.Xu,etal.;J.NeuRochem.103,2004(2007)
- Clinicalaspectsofindoleamine2,3-dioxygenase(IDO)-initiatedtryptophanmetabolism:IDOisatargetofdrugdiscoveryforvariousdiseasea:O.Takikawa;Int.Congr.Ser.1304,290(2007)
- Chemicalgeneticapproachestoprobingcelldeath:B.R.Stockwell&N.M.Gangadhar;Curr.Opin.Chem.Biol.11,83(2007)
- IdentificationofRIP1kinaseasaspecificcellulartargetofnecrostatins:A.Degterev,etal.;Nat.Chem.Biol.4,313(2008)
- RIP1-dependentandindependenteffectsofnecrostatin-1innecrosisandTcellactivation:Y.Cho,etal.;PLoSOne6,e23209(2011)
- Necrostatin-1suppressesautophagyandapoptosisinmicetraumaticbraininjurymodel:Y.Q.Wang,etal.;Neurochem.Res.37,1849(2012)
- Necrostatin-1blocksbothRIPK1andIDO:consequencesforthestudyofcelldeathinexperimentaldiseasemodels:P.Vandenabeele,etal.;CellDeathDiffer.20,185(2013)
- Activityandspecificityofnecrostatin-1,small-moleculeinhibitorofRIP1kinase:A.Degterev,etal.;CellDeathDiffer20,366(2013)
- Studyofcardioprotectiveeffectsofnecroptosisinhibitorsonisolatedratheartsubjectedtoglobalischemia-reperfusion:Y.V.Dimitriev,etal.;Bull.Exp.Biol.Med.155,245(2013)
- Necroptosisinhibitornecrostatin-1promotescellprotectionandphysiologicalfunctionintraumaticspinalcordinjury:Y.Wang,etal.;Neuroscience266,91(2014)
- Necrostatin-1protectionofdopaminergicneurons;J.R.Wu,etal.;Neural.Regen.Res.10,1120(2015)
- Protectiveroleofnecrostatin-1inacutemyocardialinfarction:F.Carbone,etal.;Eur.J.Clin.Invest.46,99(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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