Adipogen/Nargenicin A<sub>1</sub>/BVT-0204-M005/5 mg
商品编号：
BVT-0204-M005
品牌：
Adipogen Inc
市场价：
¥11200.00
美元价：
6720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | CP-47,444; CS682 |
| Product Type | Chemical |
| Properties | |
| Formula | C28H37NO8 |
| MW | 515.6 |
| CAS | 70695-02-2 |
| Source/Host Chemicals | Isolated from Actinomyces sp. Gö301. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Off-white powder. |
| Solubility | Soluble in DMSO or methanol. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | YEUSSARNQQYBKH-SIMZXIQRSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Antibiotic against Gram-positive bacteria, particularly Staphylococcus and Clostridia.
- More effective against multi-resistant strains (MRSA) than erythromycin and vancomycin.
- Inhibits cell proliferation and induces HL-60 cell differentiation in combination with 1,25-Dihydroxyvitamin-D3 and ATRA.
- Displays low cytotoxicity compared to erythromycin and spiramycin.
Product References
- Structure of natural antibiotic CP-47,444: W.D. Celmer et al., J. Am. Chem. Soc. 102, 4203-4209 (1980).
- 9-O-Esters of nodusmicin: B.J. Magerlein and S.A. Mizsak, J. Antibiot. 35, 111-112 (1981).
- Biosynthetic origin of the carbon skeleton and oxygen atoms of nargenicin A1: D.E. Cane and C. Yang, J. Am. Chem. Soc. 106, 784-787 (1984).
- Biosynthesis of nargenicin and nodusmicin: W.C. Snyder and K.L. Rinehart, jr., J. Am. Chem. Soc. 106, 787-789 (1984).
- Nargenicin biosynthesis: D.E. Cane et al., J. Am. Chem. Soc. 115, 527-535 (1993).
- The chemistry of the Nargenicin macrolides: J. Kallmerten, in Studies in natural products chemistry (Ed.: A.-U. Rahman, Elsevier)17, 283-310 (1995).
- Production, isolation and biological activity of nargenicin from Nocardia sp. CS682: J.K. Sohng et al., Arch. Pharm. Res. 31, 1339-1345 (2008).
- Quantitative analysis of nargenicin in Nocardia sp. CS682 culture by HPLC: S.S. Cho et al., Arch. Pharm. Res. 32, 335-340 (2009).
- Nargenicin attenuates lipopolysaccharide-induced responses in BV-2 cells: J.C. Yoo et al., Neuroreport 20, 1007 (2009).
- Nargenicin enhances 1,25-dihydroxyvitamin D3- and all-trans retinoic acid-induced leukemia cell differentiation via PKCbetal/MAPK pathways: S.H. Kim et al., Biochemical Pharmacology 77, 1694-1701 (2009).
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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