Adipogen/Mycophenolic acid/AG-CN2-0419-M100/100 mg
商品编号：
AG-CN2-0419-M100
品牌：
Adipogen Inc
市场价：
¥1300.00
美元价：
780.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | MPA;NSC129185;Ly68618;Mycophenolate |
| ProductType | Chemical |
| Properties | |
| Formula | C17H20O6 |
| MW | 320.3 |
| MerckIndex | 14:6327 |
| CAS | 24280-93-1 |
| RTECS | MP8050000 |
| Source/HostChemicals | IsolatedfromPenicilliumbrevi-compactum. |
| PurityChemicals | ≥98%(HPLC,TLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO,methanolorethanol.Insolubleinwater. |
| InChiKey | HPNSFSBZBAHARI-RUDMXATFSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +20°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic[1].
- Showsantiviral,antifungalandantitumorproperties[1,2].
- Immunosuppressivedrugusedtopreventrejectioninorgantransplantation,rheumatoidarthritis,andpsoriasis[3-6,13].
- PotentreversIBLeinhibitorofinosine-5"-monophosphatedehydrogenase(IMPDH),leADIngtodepletionofGMPandinterruptionofthedenovosynthesisofpurinenucleotidesnecessaryforBandTlymphocyteproliferation[7,8].
- InhibitsthetypeIIIMPDHisoform(IMPDH-2)5-foldmorepotentlycomparedtotypeIisoform[11].
- InhibitsRNAandDNAsynthesis[13].
- Induciblenitricoxidesynthase(iNOS/NOSII)inhibitor[8,10].
- Apoptosisandnecrosisinducer[9,12].
- NoveltypeofinhibitoragainstRNAguanylyltransferases[14].
- InhibitsTNF-α-stimulatedMAPK/NF-κBandROSgeneration[15].
- Autophagysuppressor.
ProductReferences
- Mycophenolicacid:antiviralandantitumorproperties:R.H.Williams,etal.;J.Antibiot.21,463(1968)
- Mycophenolicacid:ananti-cancercompoundwithunusualproperties: S.B.Carter,etal.;Nature223,848(1969)
- Treatmentofpsoriasiswithoralmycophenolicacid:E.L.Jones,etal.;J.Invest.Dermatol.65,537(1975)
- Lymphocyte-selectivecytostaticandimmunosuppressiveeffectsofmycophenolicacidinvitro:roleofdeoxyguanosinenucleotidedepeletion:E.M.Eugui,etal.;Scand.J.Immunol.33,161(1991)
- Newsmallmoleculeimmunosuppressantsfortransplantation:reviewofessentialconcepts:R.E.Morris;J.HeartLungTransplant.12,275(1993)
- ImmunosuppressiveandotherEffectsofMycophenolicAcidandanEsterProdrug,MycophenolateMofetil:A.C.Allison&E.M.Eugui;Immunol.Rev.136,5(1993)
- Mechanismsofactionofmycophenolicacid:A.C.Allison,etal.;Ann.N.Y.Acad.Sci.696,63(1993)(Review)
- Mycophenolicacid,aninhibitorofIMPdehydrogenasethatisalsoanimmunosuppressiveagent,suppressesthecytokine-inducednitricoxideproductioninmouseandratvascularendothelialcells:M.Senda,etal.;Transplantation60,1143(1995)
- Mycophenolicacidincreasesapoptosis,lysosomesandlipiddropletsinhumanlymphoidandmonocyticcelllines:R.G.Cohn,etal.;Transplantation68,411(1999)
- Induciblenitricoxidesynthaseinhibitionbymycophenolicacid:D.J.Miljkovic,etal.;MiniRev.Med.Chem.4,741(2004)
- Mechanismsofactionofmycophenolatemofetilinpreventingacuteandchronicallograftrejection:A.C.Allison&E.M.Eugui;Transplantation80,S181(2005)
- Theimmunosuppressormycophenolicacidkillsactivatedlymphocytesbyinducinganonclassicalactin-dependentnecroticsignal:B.Chaigne-Delalande,etal.;J.Immunol.181,7630(2008)
- Mycophenolicacidinrheumatology:mechanismsofactionandsevereadverseevents:G.Zizzo,etal.;Reumatismo62,91(2010)(Review)
- Virtualhigh-throughputscreeningidentifiesmycophenolicacidasanovelRNAcappinginhibitor:M.Tremblay-Letourneau,etal.;PLoSOne6,e24806(2011)
- Mycophenolicacidattenuatesthetumournecrosisfactorα-mediatedproinflammatoryresponseinendothelialcellsbyblockingtheMAPK/NF-κBandROSpathways:W.Olejarz,etal.;Eur.J.Clin.Invest. 44, 54 (2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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