Adipogen/Muristerone A/AG-CN2-0070-C250/250 µg
商品编号：
AG-CN2-0070-C250
品牌：
Adipogen Inc
市场价：
¥960.00
美元价：
576.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | 2β,3β,5β,11α,14α,20R,22R-Heptahydroxycholest-7-en-6-one |
| Product Type | Chemical |
| Properties | |
| Formula | C27H44O8 |
| MW | 496.6 |
| CAS | 38778-30-2 |
| Source/Host Chemicals | Isolated from Ipomoea hederacea seeds. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in acetic acid, ethanol, methanol or DMSO. Insoluble in water. |
| Identity | Identity determined by 1H-NMR. |
| Other Product Data | To prepare a 1mM stock solution (1.1mM) in 100% ethanol: Add 2ml of 100% ethanol to 1mg muristerone A (2µmol). Gently mix to dissolve the product (5 to 10min.). Do not heat solution to dissolve the product. Store the 1mM stock solution at +4°C or at -20°C. |
| InChi Key | LRJUYAVTHIEHAI-LDJCFVSYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Potent member of the ecdysteroid family.
- Ecdysone receptor (EcR) agonist.
- Analog of ecdysone with similar properties to ponasterone A (Prod. No. AG-CN2-0053).
- Inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals.
- Induces apoptosis in cells transfected with wild-type Bax.
- Induces expression of β-galactosidase.
- Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.
- Insect steroid hormone involved in regulating metamorphosis, causing a response to G2 cell cycle arrest.
- Major molting hormone in some insects. Has protective effects in plants.
Product References
- Structure of muristerone A, a new phytoecdysone: L. Canonica, et al.; J. C. S. Chem. Commun. 1060 (1972)
- New phytoecdysones from kaladana. I. Structure of muristerone A and kaladasterone: L. Canonica, et al.; Gazz. Chim. Ital. 107, 123 (1977)
- Characterization and partial purification of the Drosophila Kc cell ecdysteroid receptor: T.M. Landon, et al.; J. Biol. Chem. 263, 4693 (1988)
- Ecdysteroid-Dependent Regulation of Genes in Mammalian Cells by a Drosophila Ecdysone Receptor and Chimeric Transactivators: K. Christopherson, et al.; PNAS 89, 6314 (1992)
- Ecdysone-inducible gene expression in mammalian cells and transgenic mice: D. No, et al.; PNAS 93, 3346 (1996)
- The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition: J.G. Pastorino, et al.; J. Biol. Chem. 273, 7770 (1998)
- Impairment of the proapoptotic activity of Bax by missense mutations found in gastrointestinal cancers: J. Gil, et al.; Cancer Res. 59, 2034 (1999)
- Identification of ligands and coligands for the ecdysone-regulated gene switch: E. Saez, et al.; PNAS 97, 14512 (2000)
- Ectopic expression of cyclin D1 impairs the proliferation and enhances the apoptosis of a murine lymphoid cell line: F. Duquesne, et al.; Cell Death Differ. 8, 51 (2001)
- The ecdysone inducible gene expression system: unexpected effects of muristerone A and ponasterone A on cytokine signaling in mammalian cells: S. Constantino, et al.; Eur. Cytokine Netw. 12, 365 (2001)
- Muristerone A-induced nerve growth factor release from genetically engineered human dermal fibroblasts for peripheral nerve tissue engineering: C.W. Patrick, et al.; Tissue Eng. 7, 303 (2001)
- Agonists of an ecdysone-inducible mammalian expression system inhibit Fas-ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO: I Oehme, et al.; Cell Death Diff. 13, 189 (2005)
- Selected technologies to control genes and their products for experimental and clinical purposes: H.K. Alexander, et al.; Arch. Immunol. Ther. Exp. 55, 139 (2007) (Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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