Adipogen/MS-275/AG-CR1-0032-M005/5 mg
商品编号：
AG-CR1-0032-M005
品牌：
Adipogen Inc
市场价：
¥1000.00
美元价：
600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | N-(2-Aminophenyl)-4-[N-(pyridine-3-ylmethoxy-carbonyl)aminomethyl]benzamide; MS-27-275 |
| Product Type | Chemical |
| Properties | |
| Formula | C21H20N4O3 |
| MW | 376.4 |
| CAS | 209783-80-2 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Off-white to tan solid. |
| Solubility | Soluble in DMSO or methanol. |
| InChi Key | LTWMTJUZATWRDH-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- HDAC 1 inhibitor [1, 2].
- Antitumor compound [1-3].
- Antiproliferative [2].
- TGF-β type II receptor inducer [2].
- Apoptosis inducer [4].
- Anti-inflammatory [5].
- Angiogenesis inhibitor [6].
- Review [7].
- Promotes either self-renewal or differentiation of embryonic stem cells [8].
Product References
- A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors: A. Saito, et al.; PNAS 96, 4592 (1999)
- MS-275, a histone deacetylase inhibitor, selectively induces transforming growth factor beta type II receptor expression in human breast cancer cells: B.I. Lee, et al.; Cancer Res. 61, 931 (2001)
- MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumors: J. Jaboin, et al.; Cancer Res. 62, 6108 (2002)
- The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1: R.R. Rosato, et al.; Cancer Res. 63, 3637 (2003)
- MS-275, an histone deacetylase inhibitor, reduces the inflammatory reaction in rat experimental autoimmune neuritis: Z.Y. Zhang, et al.; Neuroscience 169, 370 (2010)
- S-275 sensitizes TRAIL-resistant breast cancer cells, inhibits angiogenesis and metastasis, and reverses epithelial-mesenchymal transition in vivo: R.K. Srivastava, et al.; Mol. Cancer Ther. 9, 3254 (2010)
- MS-275, a potent orally available inhibitor of histone deacetylases--the development of an anticancer agent: H. Hess-Stumpp, et al.; Int. J. Biochem. Cell Biol. 39, 1388 (2007)
- Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming: A. Kretsovali, et al.; Stem Cells Int. 2012, 1 (2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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