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当前位置: 首页 > 产品中心 > Other_reagents > Adipogen/MPLA (synthetic) Sterile Solution/AG-CU1-0002-C100/100 µg
商品详细Adipogen/MPLA (synthetic) Sterile Solution/AG-CU1-0002-C100/100 µg
Adipogen/MPLA (synthetic) Sterile Solution/AG-CU1-0002-C100/100 µg
Adipogen/MPLA (synthetic) Sterile Solution/AG-CU1-0002-C100/100 µg
商品编号: AG-CU1-0002-C100
品牌: Adipogen Inc
市场价: ¥5000.00
美元价: 3000.00
产地: 美国(厂家直采)
公司:
产品分类: 其他试剂
公司分类: Other_reagents
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
More Information
Product Details
Synonyms Monophosphoryl Lipid A; Phosphorylated Hexaacyl Disaccharide; Glycopyranoside Lipid A; Glucopyranosyl Lipid Adjuvant; GLA
Product Type Chemical
Properties
Formula C96H184N3O22P
MW 1763.47
CAS 1246298-63-4
Source/Host Chemicals Synthetic. Does not contain RNA, DNA or protein fragments.
Purity Chemicals No detectable TLR4 independent activity: standardised TLR4-specific agonist.
Appearance Colourless opaque aqueous solution.
Formulation Liquid.
Concentration 0.5mg/ml stabilized in sterile, double-distilled water (ddWater), without any additives.
Other Product Data Preparation of Stock Solution: To yield a 50μg/ml (500-50x) stock solution add 100μl of MPLA to 900μl endotoxin-free and sterile ddWater (Cat. No.: IAX-900-002) (not PBS) and mix well.
InChi Key UPAZUDUZKTYFBG-UCUVALOBDI
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Do not freeze.
Ready-made solution is cell culture-grade. Prepare diluted MPLA working solutions in water just prior to use, keep sterile.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Toll-like receptor 4 (TLR4) activator. Activates TLR4 but does not activate TLR2 even at high concentrations.
  • Defined structure of MPLA.
  • Synthetic lipid A is structurally very similar to natural MPLA but does not exist in nature.
Product References
  1. Biological activities of synthetic lipid A analogs: pyrogenicity, lethal toxicity, anticomplement activity, and induction of gelation of Limulus amoebocytelysate: K. Tanamoto, et al.; Infect. Immun. 44, 42 (1984)
  2. Endotoxic properties of chemically synthesized lipid A part structures. Comparison of synthetic lipid A precursor and synthetic analogues with biosynthetic lipid A precursor and free lipid A: C. Galanos, et al.; Eur. J. Biochem. 140, 221 (1984)
  3. Role of innate immune factors in the adjuvant activity of monophosphoryl lipid A: M. Martin, et al.; Infect. Immun. 71, 2498 (2003)
  4. Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4 and myeloid differentiation factor 88-dependent signaling pathway: M. Martin, et al.; Int. Immunol. 14, 1325 (2003)
  5. Synthetic and natural TLR4 agonists as safe and effective vaccine adjuvants: C.B. Fox, et al.; Subcell. Biochem. 53, 303 (2010)
  6. A synthetic adjuvant to enhance and expand immune responses to influenza vaccines: R.N. Coler, et al.; PLoS One 5, e13677 (2010)
  7. CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS: T. Regen, et al.; Brain Behav. Immun. 25, 957 (2011)
品牌介绍
Adipogen公司由三个子公司组成,分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国,运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发,如癌症、免疫、炎症、代谢疾病(糖尿病、肥胖)、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外,也可提供抗体和蛋白产品,Adipogen拥有自己的化学实验室,致力于开发创新型小分子化合物。