![Adipogen/MLN4924 [NAE Inhibitor] Solution/AG-CS1-0103-M001/1 mg](https://www.ebiomall.cn/images/adipogen/ag-cs1-0103_mln4924_solution.png)
Adipogen/MLN4924 [NAE Inhibitor] Solution/AG-CS1-0103-M001/1 mg
商品编号：
AG-CS1-0103-M001
品牌：
Adipogen Inc
市场价：
¥4060.00
美元价：
2436.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Pevonedistat; Nedd8 E1 Activating Enzyme Inhibitor |
| Product Type | Chemical |
| Properties | |
| Formula | C21H25N5O4S |
| MW | 443.5 |
| CAS | 905579-51-3 |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | Liquid. |
| Formulation | 20mM stock solution in DMSO. |
| Declaration | Manufactured by Boston Biochem |
| InChi Key | MPUQHZXIXSTTDU-QXGSTGNESA-N |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stock solutions are stable for at least 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Potent, selective and cell-permeable inhibitor of Nedd8 E1 Activating Enzyme (NAE).
- By inhibiting the Neddylation pathway this molecule disrupts cullin-RING ligase activity, leading to inhibition of proliferation or apoptotic death of various human tumor cells through the deregulation of S-phase DNA synthesis.
- Angiogenesis inhibitor.
Product References
- An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer: T.A. Soucy, et al.; Nature 458, 7239 (2009)
- MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells: Y. Gu, et al.; Blood 123, 3269 (2014)
- NEDD8-activating enzyme inhibitor, MLN4924 (Pevonedistat) induces NOXA-dependent apoptosis through up-regulation of ATF-4: X. Liu, et al.; BBRC 488, 1 (2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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