Adipogen/Miglitol/AG-CR1-3635-M010/10 mg
商品编号：
AG-CR1-3635-M010
品牌：
Adipogen Inc
市场价：
¥1300.00
美元价：
780.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(2-hydroxymethyl)-3,4,5-piperidinetriol;BAY-1099;Diastabol;Glyset;Seibule |
| ProductType | Chemical |
| Properties | |
| Formula | C8H17NO5 |
| MW | 207.2 |
| CAS | 72432-03-2 |
| RTECS | TN4350170 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitesolid. |
| Solubility | SolubleinwaterorDMSO. |
| Identity | Identitydeterminedby1H-NMR. |
| InChiKey | IBAQFPQHRJAVAV-ULAWRXDQSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +20°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Keepcoolanddry. Protectfrommoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Anti-diabeticagentwithantihyperglycemicactivity.α-Glucosidaseinhibitor.Inhibitslysosomalα-glucosidase,sucrase,maltaseandisomaltase(IC50=0.35,0.11,1.3,and1.2μM,respectively)aswellasmaltase-glucoamylase(IC50=1.0μM).
- α-Glucosidaseenzymeshydrolyzeoligosaccharidesanddisaccharidesintoglucoseandothermonosaccharides.Inhibitionbymiglitolpreventsthebreakdownoflargercarbohydratesintoglucose.Thissuppressespostprandialhyperglycemiaandreducesplasmaglucoseconcentrationinnormalratsandinseveralanimalmodelsofdiabeteswithoutcardiovascularcomplications.
- Anti-obesitydrug.ShowntoinhibitADIpogenesisofwhiteadipocytesinvitroandtoactivatebrownadiposetissue(BAT)inmice.
- Inducesanenhancedandprolongedreleaseofglucagon-likepeptide-1,regulatingappetiteandstabilizingbodyweightinhumans.
- Influencedbileacidmetabolisminmiceandregulatedthesecretionofincretinhormonesinhumans.
- Reducesplasmalipidsandinhibitsfreeradicalgeneration.Inhibitsoxidativestress-inducedapoptosisandmitochondrialROSoverproductioninendothelialcells.
ProductReferences
- Miglitol,anewα-glucosidaseinhibitor: J.P.Sels,etal.;Expert.Opin.Pharmacother.1,149(1999)(Review)
- Theeffectsofmiglitolonglucagon-likepeptide-1secretionandappetitesensationsinobesetype2diabetics:A.Lee,etal.;DiabetesObes.Metab.4,329(2002)
- Invitroinhibitionofglycogen-degradingenzymesandglycosidasesbysix-memberedsugarmimicsandtheirevaluationincellcultures:C.Kuriyama,etal.;Biorg.Med.Chem.16,7330(2008)
- Probingtheactive-siterequirementsofhumanintestinalN-terminalmaltase-glucoamylase:Synthesisandenzymeinhibitoryactivitiesofasix-memberedringnitrogenanalogueofkotalanolanditsde-O-sulfonatedderivative:S.Mohan,etal.; Biorg.Med.Chem.18,7794(2010)
- ThesynthesisandBIOLOGicalevaluationof1-C-alkyl-L-arabinoiminofuranoses,anovelclassofα-glucosidaseinhibitors:Y.Natori,etal.;Bioorg.Med.Chem.Lett.21,738(2011)
- Alpha-glucosidaseinhibitors2012-cardiovascularconsiderationsandtrialevaluation:E.Standl&O.Schnell;Diab.Vasc.Dis.Res. 9,163(2012)
- Miglitol,ananti-diabeticdrug,inhibitsoxdiativestress-inducedapoptosisandmitochondrialROSover-productioninendothelialcellsbyenhancementofAMP-activatedproteinkinase:C.Aoki,etal.;J.Pharmacol.Sci.120,121(2012)
- Miglitolpreventsdiet-inducedobesitybystimulatingbrownadiposetissueandenergyexpenditureindependentofpreventingthedigestionofcarbohydrates:T.Sasaki,etal.;Endocr.J.60,1117(2013)
- Lipidloweringandantioxidanteffectofmiglitolintritontreatedhyperlipidemicandhighfatdietinducedobeserats:A.Shrivastava,etal.;Lipids48,597(2013)
- Miglitolincreasesenergyexpenditurebyupregulatinguncouplingprotein1ofbrownadiposetissueandreducesobesityindietary-inducedobesemice:S.Sugimoto,etal.;Nutr.Metab.(Lond)11,14(2014)
- Review:Miglitolhaspotentialasatherapeuticdrugagainstobesity:S.Sugimoto,etal.;Nutr.Metab.(Lond)12,51(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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