![Adipogen/MI-2 [MALT1 Inhibitor]/AG-CR1-3661-M025/25 mg](https://www.ebiomall.cn/images/adipogen/ag-cr1-3661_mi-2.png)
Adipogen/MI-2 [MALT1 Inhibitor]/AG-CR1-3661-M025/25 mg
商品编号：
AG-CR1-3661-M025
品牌：
Adipogen Inc
市场价：
¥7200.00
美元价：
4320.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | 2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide; ALB-H03200218 |
| Product Type | Chemical |
| Properties | |
| Formula | C19H17Cl3N4O3 |
| MW | 455.7 |
| CAS | 1047953-91-2 |
| Purity Chemicals | ≥98% |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (30mg/ml) or ethanol (5mg/ml). |
| InChi Key | TWJGQZBSEMDPQP-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Highly potent and selective irreversible MALT1 inhibitor (IC50=5.8μM). Binds directly to MALT1 and suppresses protease function.
- Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 (EC50= ~200nM and ~500nM for HBL-1 and TMD8, respectively) activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines in vitro and xenotransplanted mouse ABC-DLBCL tumors in vivo and primary human ABC-DLBCLs ex vivo.
- In combination with bryostatin 1 displays selective killing of HIV latently infected CD4+ T cells.
- Inhibits NF-κB and NLRP3 inflammasome activation in macrophages. Decreased production of IL-1β/IL-18 in PMA-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-κB and NLRP3 inflammasome.
Product References
- MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo: L. Fontan, et al.; Cancer Cell 22, 812 (2012)
- MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation: W. Liu, et al.; Oncotarget 7, 30536 (2016)
- Short Communication: Preferential Killing of HIV Latently Infected CD4(+) T Cells by MALT1 Inhibitor: H. Li, et al.; AIDS Res. Hum. Retroviruses 32, 174 (2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
