![Adipogen/MI-2 [MALT1 Inhibitor]/AG-CR1-3661-M005/5 mg](https://www.ebiomall.cn/images/adipogen/ag-cr1-3661_mi-2.png)
Adipogen/MI-2 [MALT1 Inhibitor]/AG-CR1-3661-M005/5 mg
商品编号：
AG-CR1-3661-M005
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide;ALB-H03200218 |
| ProductType | Chemical |
| Properties | |
| Formula | C19H17Cl3N4O3 |
| MW | 455.7 |
| CAS | 1047953-91-2 |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO(30mg/ml)orethanol(5mg/ml). |
| InChiKey | TWJGQZBSEMDPQP-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- HighlypotentandselectiveirreversIBLeMALT1inhibitor(IC50=5.8μM).BindsdirectlytoMALT1andsuppressesproteasefunction.
- DecreasesNF-κBactivityinducedbyMALT1.InhibitscellproliferationandMALT1-mediatedcleavageactivity.SuppresseshumanTMD8andHBL-1(EC50=~200nMand~500nMforHBL-1andTMD8,respectively)activatedBcell-likediffuselargeBcelllymphoma(ABC-DLBCL)celllinesinvitroandxenotransplantedmouseABC-DLBCLtumorsinvivoandprimaryhumanABC-DLBCLsexvivo.
- Incombinationwithbryostatin1displaysselectivekillingofHIVlatentlyinfectedCD4+Tcells.
- InhibitsNF-κBandNLRP3inflammasomeactivationinmacrophages.DecreasedproductionofIL-1β/IL-18inPMA-differentiatedTHP-1cellsandbonemarrowderivedmacrophageviasuppressingtheactivationofNF-κBandNLRP3inflammasome.
ProductReferences
- MALT1smallmoleculeinhibitorsspecificallysuppressABC-DLBCLinvitroandinvivo:L.Fontan,etal.;CancerCell22,812(2012)
- MALT1inhibitorspreventthedevelopmentofDSS-inducedexperimentalcolitisinmiceviainhibitingNF-κBandNLRP3inflammasomeactivation:W.Liu,etal.;Oncotarget7,30536(2016)
- ShortCommunication:PreferentialKillingofHIVLatentlyInfectedCD4(+)TCellsbyMALT1Inhibitor:H.Li,etal.;AIDSRes.Hum.Retroviruses32,174(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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