Adipogen/Menadione/AG-CR1-3631-G005/5 g
商品编号：
AG-CR1-3631-G005
品牌：
Adipogen Inc
市场价：
¥700.00
美元价：
420.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | VitaminK3;NSC4170;2-Methyl-1,4-naphthalenedione |
| ProductType | Chemical |
| Properties | |
| Formula | C11H8O2 |
| MW | 172.2 |
| CAS | 58-27-5 |
| RTECS | QL9100000 |
| PurityChemicals | ≥98% |
| Appearance | Off-whitetoyellowsolid. |
| Solubility | SolubleinDMSO(20mg/ml),ethanol(10mg/ml)ordimethylformamide(30mg/ml).Insolubleinwater. |
| InChiKey | MJVAVZPDRWSRRC-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Keepunderinertgas. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- SyntheticnaphthoquinonewithouttheisoprenoidsidechainandBIOLOGicalactivity,butcanbeconvertedtoactivevitaminK2(menaquinone)afteralkylationinvivo.The1,4-naphthoquinone(NQ)moietycanformredoxisomersbyacceptingoneortwoelectronsrespectively.Thequinoneredoxcyclingabilityleadstothegenerationofreactiveoxygenspecies(ROS)aswellasarylationreactions.
- Anticancercompound.Apoptosisinducerinvariousculturedcellsincludingleukemiathroughseveralmodesofaction.
- FreerADIcalgenerator.Producesperoxideandsuperoxideradicals(ROS)leadingtomitochondrialdysfunction.
- Cellcycleinhibitor.Glutathione(GSH)depletionresultsbydirectarylationofcellularthiols.OnceGSHisdepleted,cellularmacromoleculesstarttobealkylated,resultingintheirinactivation.
- Proteintyrosinephosphataseinhibitor.
- InhibitorofmitochondrialDNApolymeraseγ.
- Inhibitorofindoleamine2,3-dioxygenase(IDO)withanIC50of~1μM.
ProductReferences
- VitaminK3inducescellcyclearrestandcelldeathbyinhibitingCdc25phosphatase:F.Y.WuandT.P.;Eur.J.Cancer35,1388(1999)
- Apoptosis-inducingactivityofvitaminCandvitaminK:H.Sakagami,etal.;CellMol.Biol.46,129(2000)
- CytotoxicactivityofvitaminsK1,K2andK3againsthumanoraltumorcelllines:H.Okayasu,etal.;AnticancerRes.21,2387(2001)
- 2-Methyl-1,4-naphthoquinone,vitaminK(3),decreasesgap-junctionalintercellularcommunicationviaactivationoftheepidermalgrowthfactorreceptor/extracellularsignal-regulatedkinasecascade:L.O.Klotz,etal.;CancerRes.62,4922(2002)
- Signalingeffectsofmenadione:fromtyrosinephosphataseinactivationtoconnexinphosphorylation:K.ABDelmohsen,etal.;MethodsEnzymol.378,258(2004)(Review)
- VitaminK3(menadione)-inducedoncosisassociatedwithkeratin8phosphorylationandhistoneH3arylation:G.K.Scott,etal.;Mol.Pharmacol.68,606(2005)
- Menadione-inducedreactiveoxygenspeciesgenerationviaredoxcyclingpromotesapoptosisofmurinepancreaticacinarcells:D.N.Criddle,etal.;J.Biol.Chem.281,40485(2006)
- ActivationofErbB2by2-methyl-1,4-naphthoquinone(menadione)inhumankeratinocytes:roleofEGFRandproteintyrosinephosphatises:J.I.Beier,etal.;FEBSLett.580,1859(2006)
- InhibitionofPTENandactivationofAktbymenadione:K.Yoshikawa,etal.;Biochim.Biophys.Acta1770,687(2007)
- Indoleamine2,3-DioxygenaseIstheAnticancerTargetforaNovelSeriesofPotentNaphthoquinone-BasedInhibitors:S.Kumar,etal.;J.Med.Chem.51,1706(2008)
- DNApolymerasegammainhibitionbyvitaminK3inducesmitochondria-mediatedcytotoxicityinhumancancercells:R.Sasaki,etal.;CancerSci.99,1040(2008)
- Targetingcancercellsbyanoxidant-basedtherapy:J.Verrax,etal.;Curr.Mol.Pharmacol.1,80(2008)(Review)
- Thephosphataseinhibitormenadione(vitaminK3)protectscellsfromEGFRinhibitionbyerlotinibandcetuximab:R.Perez-Soler,etal.;Clin.CancerRes.17,6766(2011)
- 1,4-naphthoquinones:fromoxidativedamagetocellularandinter-cellularsignalling:L.O.Klotz,etal.;Molecules19,14902(2014)
- AnticancerVitaminK3analogues:Areview:K.D.Badave,etal.;AnticancerAgentsMed.Chem.(Epubaheadofprint)(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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