脂肪原/MCC950。钠盐/AG-CR1-3615-M010/10 mg
商品编号：
AG-CR1-3615-M010
品牌：
Adipogen Inc
市场价：
¥2800.00
美元价：
1680.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | MCC950;CP-456,773;CRID3;1-(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]urea |
| ProductType | Chemical |
| Properties | |
| Formula | C20H23N2NaO5S |
| MW | 426.5 |
| CAS | 256373-96-3 |
| PurityChemicals | ≥97%(HPLC) |
| Appearance | Crystallinesolid. |
| Solubility | Solubleinwater,DMSO,dimethylformamideorethanol. |
| Identity | Determinedby1H-NMR. |
| InChiKey | SNIGCXULUAXYGW-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potent,selectiveandorallyavailableNLRP3inflammasomeinhibitor.
- BlocksthereleaseofIL-1βinmacrophagesprimedwithLPSandactivatedwithATPornigericin,butitdoesnotinhibitNLRP1,NLRC4,AIM2,TLR2signalingorprimingofNLRP3.
- PreventsoligomerizationofASCincellsstimulatedwithLPSandnigericin.
- Activeinvivo,blockingtheproductionofIL-1βandenhancingsurvivalinmousemodelsofmultiplesclerosisandcryopyrin-associatedperiodicsyndrome(CAPS).AlsoactiveinexvivosamplesfromindividualswithMuckle-Wellssyndrome.
- PotentialtherapeuticagentforNLRP3-associatedsyndromes,includingautoinflammatoryandautoimmunediseases.
ProductReferences
- Glutathiones-transferaseomega1-1isatargetofcytokinereleaseinhibitorydrugsandmayberesponsIBLefortheireffectoninterleukin-1betaposttranslationalprocessing:R.E.Laliberte,etal.;J.Biol.Chem.278,16567(2003)
- Novelsynthesisof1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(1-hydroxy-1-methylethyl)furan-2-sulfonyl]urea,anantiinflammatoryagent:F.J.Urban,etal.;Synth.Commun.33,2029(2003)
- ThecytokinereleaseinhibitorydrugCRID3targetsASColigomerisationintheNLRP3andAIM2inflammasomes:R.C.Coll,etal.;PLoSOne6,e29539(2011)
- Asmall-moleculeinhibitoroftheNLRP3inflammasomeforthetreatmentofinflammatorydiseases:R.C.Coll,etal.;Nat.Med.21,248(2015)
- Tamingtheinflammasome:M.Levy,etal.;Nat.Med.21,213(2015)
- TheNlrp3inflammasomeadmitsdefeat:C.J.Gross&O.Gross;TrendsImmunol.36,323(2015)
- P2X7receptorantagonismpreventsIL-1βreleasefromsalivaryepithelialcellsandreducesinflammationinamousemodelofautoimmuneexocrinopathy:M.G.Khalafalla,etal.;J.Biol.Chem.292,16626(2017)
- InhibitionoftheNOD-likereceptorprotein3inflammasomeIsprotectiveinjuvenileinfluenzaAvirusinfection:B.M.Coates,etal.;Front.Immunol.8,782(2017)
- MCC950,theselectiveNLRP3inflammasomeinhibitorprotectsmiceagainsttraumaticbraininjury:S.Ismael,etal.;J.Neurotrauma,aheadofprint(2017)
- InhibitoryEffectandMechanismofArctiumlappaExtractonNLRP3InflammasomeActivation:Y.K.Kim,etal.;Evid.Compl.Altern.Med.6346734(2018)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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