Adipogen/MBIMPH F-Analog 1 . hydrochloride/AG-CR1-3908-M005/5 mg
商品编号：
AG-CR1-3908-M005
品牌：
Adipogen Inc
市场价：
¥12000.00
美元价：
7200.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | MBIMPHFluorinatedAnalog1;3-Fluoro-N-hydroxy-4-((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)benzamide |
| ProductType | Chemical |
| Properties | |
| Formula | C16H14FN3O2.HCl |
| MW | 299.3.36.5 |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Off-whitesolid. |
| Solubility | SolubleinDMSO,ethanol,methanolorwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | NWMOSGPUNITEFR-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeable,potentandselectiveclassIIbHDAC6inhibitor(IC50=3nM).DisplayshighselectivityoverallotherHDACs(IC50=0.03-20µM).
- Inducescellularα-tubulin,butnothistoneH3hyperacetylationinNeuro-2acells.Promotesmitochondrialtransport.
- ShowsimprovedkineticsandbiochemicalpotencyagainstHDAC6comparedtotubastatinA(AG-CR1-3900).
- HDAC6deacetylatestubulin,HSP90andthecorehistones(H2A,H2B,H3,H4).Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.HDAC6playsanimportantroleinmicrotubule-dependentcellmotility,transcriptionalregulation,degradationofmisfoldedproteinsandcellcycleandisinvolvedinautophagy,inflammation,cancerandneurodegeneration.
ProductReferences
- Bicyclic-cappedhistonedeacetylase6inhibitorswithimprovedactivityinamodelofaxonalcharcot-marie-toothdisease:S.Shen,etal.;ACSChemicalNeuroscience(submitted)(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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