Adipogen/MBIMPH/AG-CR1-3907-M001/1 mg
商品编号：
AG-CR1-3907-M001
品牌：
Adipogen Inc
市场价：
¥3000.00
美元价：
1800.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | N-Hydroxy-4-((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)benzamide |
| Product Type | Chemical |
| Properties | |
| Formula | C16H15N3O2 |
| MW | 281.3 |
| CAS | 1392835-53-8 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | SGZCUGGIJNIVPP-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =9nM). Displays high selectivity over all other HDACs (IC50=0.1-12µM).
- Induces cellular α-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport.
- Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (Prod. No. AG-CR1-3900).
- HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
Product References
- Bicyclic-capped histone deacetylase 6 inhibitors with improved activity in a model of axonal charcot-marie-tooth disease: S. Shen, et al.; ACS Chemical Neuroscience (submitted) (2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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