脂肪原/曼扎明A/AG-CN2-0438-C500/500µg
商品编号：
AG-CN2-0438-C500
品牌：
Adipogen Inc
市场价：
¥2800.00
美元价：
1680.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | KeramamineA |
| ProductType | Chemical |
| Properties | |
| Formula | C36H44N4O |
| MW | 548.8 |
| CAS | 104196-68-1 |
| Source/HostChemicals | IsolatedfromXestospongiasp. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Yellowoil. |
| Solubility | SolubleinDMSO,ethanolormethanol. |
| InChiKey | CSJUQSWULVSLGK-ILRBDQACSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic.AntibacterialagainstGrampositiveandGramnegativebacteria.
- Exhibitschemotherapeuticactivity.Blockstumorcellinvasionandrestorescancercellsusceptibilitytoapoptosisinvitro.
- UncouplesvacuolarATPases,inhibitingautophagyandtumorgrowth.
- Antimalaria,antifungalandantiviralagent.
- GSK-3βinhibitor.
- Anti-Alzheimer"sagent.Decreasedtauhyperphosphorylation.
- Anti-hyperlipidemic.Inhibitscholesterolesterformationandacyl-CoA:cholesterolacyl-transferase(ACAT)activityinvitroanddecreasestotalcholesterol,triglyceridesandLDLlevels.
- Anti-atherosclerotic.Inhibitsfoamcellformationinmacrophages.
ProductReferences
- Fournewbioactivemanzamine-typealkaloidsfromthePhilippinemarinespongeXestospongiaashmorica:R.A.Edrada,etal.;J.Nat.Prod.59,1056(1996)
- Invivoantimalarialactivityofthebeta-carbolinealkaloidmanzamineA:K.K.Ang,etal.;Antimicrob.AgentsChemother.44,1645(2000)
- Immune-mediatedparasiteclearanceinmiceinfectedwithPlasmodiumbergheifollowingtreatmentwithmanzamineA:K.K.Ang,etal.;Parasitol.Res.87,715(2001)
- SpectrofluorimetricdeterminationofmanzamineAinspikedhumanurineandplasma:A.Khalil,etal.;Pharmazie58,385(2003)
- NewmanzaminealkaloidswithactivityagainstinfectiousandtropicalparasiticdiseasesfromanIndonesiansponge:K.V.Rao,etal.;J.Nat.Prod.66,823(2003)
- NewmanzaminealkaloidsfromanIndo-Pacificsponge.Pharmacokinetics,oralavailability,andthesignificantactivityofseveralmanzaminesagainstHIV-I,AIDSopportuNISTicinfections,andinflammatorydiseases:M.Yousaf,etal.;J.Med.Chem.47,3512(2004)
- Glycogensynthasekinase-3(GSK-3)inhibitoryactivityandstructure-activityrelationship(SAR)studiesofthemanzaminealkaloids.PotentialforAlzheimer"sdisease:M.Hamann,etal.;J.Nat.Prod.70,1397(2007)
- ManzamineAasanovelinhibitorofherpessimplexvirustype-1replicationinculturedcornealcells:J.R.Palem,etal.;PlantaMed.77,46(2011)
- Anovelactivityfromanoldcompound:ManzamineAreducesthemetastaticpotentialofAsPC-1pancreaticcancercellsandsensitizesthemtoTRAIL-inducedapoptosis:E.A.Guzman,etal.;Invest.NewDrugs29,777(2011)
- ManzamineA,amarine-derivedalkaloid,inhibitsaccumulationofcholesterolesterinmacrophagesandsuppresseshyperlipidemiaandatherosclerosisinvivo:K.Eguchi,etal.;Bioorg.Med.Chem.21,3831(2013)
- ThemarinenaturalproductmanzamineAtargetsvacuolarATPasesandinhibitsautophagyinpancreaticcancercells:G.Kallifatidis,etal.;Mar.Drugs11,3500(2013)
- AR-A014418usedagainstGSK3betadownregulatesexpressionofhnRNPA1andSF2/ASFsplicingfactors:A.K.Yadav,etal.;J.Oncol.2014,695325(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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