脂肪原/马努霉素A/BVT-0091-M005/5 mg
商品编号：
BVT-0091-M005
品牌：
Adipogen Inc
市场价：
¥6600.00
美元价：
3960.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| ProductType | Chemical |
| Properties | |
| Formula | C31H38N2O7 |
| MW | 550.6 |
| CAS | 52665-74-4 |
| Source/HostChemicals | IsolatedfromStreptomycesparvulus. |
| PurityChemicals | ≥96%(HPLC) |
| Appearance | Yellowtobrownpowder. |
| Solubility | SolubleinDMSOormethanol;insolubleinwater. |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | TWWQHCKLTXDWBD-MVTGTTCWSA-N |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic.
- Apoptosisandendoplasmicreticulumstress-mediatedcelldeathinducer.
- Potent,selectiveandcompetitivecellpermeablerasfarnesyltransferaseinhibitor(IC50=30nM).
- Doesnotaffectgeranylgeranyltransferase(IC50=180µM).
- Inhibitioniscompetitivewithrespecttofarnesylpyrophosphateandnon-competitivewithrespecttoRas.
- Neutralsphingomyelinaseinhibitor.
- Blocksinsulin-inducedMAPkinaseactivationinratcardiacmyocytes(19µM).
- Targetsproteinphosphatase1α(PP1α)andreduceshydrogenperoxide.
- CorrectsaberrantsplicingofthemusclechloridechannelClcn1inmyotonicdystrophytype1(DM1).
- Showspotentialanti-inflammatoryactivity.
ProductReferences
- IdentificationofRasfarnesyltransferaseinhibitorsbymicrobialscreening:M.Haraetal.;PNAS90,2281(1993)
- InhibitorsofRasfarnesyltransferases:F.Tamanoi;TIBS18,349(1993),(Review)
- Farnesyltransferaseinhibitors:Rasresearchyieldsapotentialcancertherapeutic:J.B.Gibbs,etal.;Cell77,175(1994)
- ProteinkinaseC,butnottyrosinekinasesorRas,playsacriticalroleinangiotensinII-inducedactivationofRaf-1kinaseandextracellularsignal-regulatedproteinkinasesincardiacmyocytes:Y.Zouetal.;J.Biol.Chem.271,33592(1996)
- ManumycininhibitsrassignaltransductionpathwayandinducesapoptosisinCOLO320-DMhumancolontumourcells:A.DiPaolo,etal.;Br.J.Cancer82,905(2000)
- ManumycinAanditsanaloguesareirreversIBLeinhibitorsofneutralsphingomyelinase:C.Arenz,etal.;ChemBioChem2,141(2001)
- EnhancementofmanumycinA-inducedapoptosisbymethoxyamineinmyeloidleukemiacells:M.She,etal.;Leukemia19,595(2005)
- BindingofmanumycinAinhibitsIkappaBkinasebetaactivity:M.Bernier,etal.;J.Biol.Chem.281,2551(2006)
- Ayeast-basedgenomicstrategyhighlightsthecellproteinnetworksalteredbyFTaseinhibitorpeptidomimetics:G.Porcu,etal.;Mol.Cancer9:197(2010)
- Targetingfarnesyl-transferaseasanoveltherapeutCSTrategyformevalonatekinasedefiency:Invitroandinvivoapproaches:L.DeLeo,etal.;Pharmacol.Res.61,506(2010)
- ManumycinAcorrectsaberrantsplicingofClcn1inmyotonicdystrophytype1(DM1)mice:K.Oana,etal.;Sci.Rep.3,2142(2013)
- Manumycininducesapoptosisinprostatecancercells:J.G.Li,etal.,OncoTargetsTher.7,771(2014)
- ThenaturaltumorcideManumycin-Atargetsproteinphosphatase1αandreduceshydrogenperoxidetoinducelymphomaapoptosis.G.B.Carey,etal.;Exp.Cell.Res.332,136(2015)
- ManumycinAfromanewstreptomycesstraininducesendoplasmicreticulumstress-mediatedcelldeaththroughspecificityprotein1signalinginhumanoralsquamouscellcarcinoma:C.J.Jae,etal.;Int.J.Oncol.47,1954(2015)
- ManumycinAdownregulatesreleaseofproinflammatorycytokinesfromTNFalphastimulatedhumanmonocytes:E.Cecrdlova,etal.;Immunol.Lett.169,8(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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