Adipogen/Malformin A1/AG-CN2-0169-C250/250 µg
商品编号：
AG-CN2-0169-C250
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | MalforminA;Cyclic(D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-isoleucyl)cyclic(1-2)-disulfide |
| ProductType | Chemical |
| Properties | |
| Formula | C23H39N5O5S2 |
| MW | 529.7 |
| CAS | 3022-92-2 |
| RTECS | ON7050000 |
| Source/HostChemicals | Synthetic.OriginallyisolatedfromAspergillusniger. |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO. |
| Declaration | SynthesizedbytheOrganicChemistryGroupofTheKitasatoInstitute. |
| InChiKey | BEZOVOWRERTMCU-VEXWFWOFSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Peptideantibiotic.Antibcaterial[1].
- Plantgrowthstimulator[2].
- Inducesrootcurvatureandmalformationinplants[3].
- Mycotoxin[4].
- Preventsinterleukin-1(IL-1)inducedendothelialchangesbyinhibitionofproteinsynthesis[5].
- Inhibitorofinterleukin-1β(IL1β)bindingtoitsreceptor[6].
- Enhancerofcellularfibrinolyticactivity[7,12].
- DisruptsthecellcycleattheG2checkpointofcancercells,leADIngtosensitizationofthecancercellstoanti-cancerreagents[8].
- Anticancercompound.Cytotoxicagainstseveralcancercelllines[9].
- Antimalarialandantitrypanosomal[10].
- InhibitorofBRAF-mutatedmelanomacelllines[11].
ProductReferences
- Antibioticpropertiesofmalformin:S.Suda&R.W.Curtis;Appl.Microbiol.14,475(1966)
- StimulationofplantgrowthbymalforminA:W.W.John&R.W.Curtis;Experientia30,1392(1974)
- StructureandsynthesisofmalforminA1:M.Bodanszky&G.L.Stahl;Bioorg.Chem.4,93(1975)
- Mycotoxinsfrommoldfungi-weaponsofuninvitedfellow-boardersofmanandanimal:structures,BIOLOGicalactivity,biosynthesis,andprecautions:B.Franck;Angew.Chem.Int.Ed.23,493(1984)
- MalforminApreventsIL-1inducedendothelialchangesbyinhibitionofproteinsynthesis:P.G.Bannon,etal.Thromb.Haemost.72,482(1994)
- Malformin-A1inhibitsthebindingofinterleukin-1beta(IL1beta)andsuppressestheexpressionoftissuefactorinhumanendothelialcellsandmonocytes:J.M.Herbert,etal.;Biochem.Pharmacol.48,1211(1994)
- EnhancementoffibrinolyticactivityofU937cellsbymalforminA1:Y.Koizumi&K.Hasumi;J.Antibiot.55,78(2002)
- Fungalmalforminsinhibitbleomycin-inducedG2checkpointinJurkatcells:K.Hagimori,etal.;Biol.Pharm.Bull.30,1379(2007)
- AsperpyroneDandothermetabolitesoftheplant-associatedfungalstrainAspergillustubingensis.J.Zhan,etal.;Phytochem.68,368(2007)
- Solid-phasesynthesisandbiologicalactivityofmalforminCanditsderivatives:Y.Kojima,etal.;J.Antibiot.(Tokyo)62,681(2009)
- Acell-basedscreeningtodetectinhibitorsofBRAFsignalingpathway:Y.Asami,etal.;J.Antibiot.62,105(2009)
- Fibrinolyticactivationpromotedbythecyclopentapeptidemalformin:involvementofcytoskeletalreorganization:Y.Koizumi,etal.;Biol.Pharm.Bull.34,1426(2011)
- MalforminA1treatmentaltersinvasiveandoncogenicphenotypesofhumancolorectalcancercellsthroughstimulationofthep38signalingpathway:SY.Park,etal.;Int.J.Oncol.51,959(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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