Adipogen/LY-333,531 . hydrochloride/AG-CR1-0087-M005/5 mg
商品编号：
AG-CR1-0087-M005
品牌：
Adipogen Inc
市场价：
¥4200.00
美元价：
2520.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Ruboxistaurin |
| ProductType | Chemical |
| Properties | |
| Formula | C28H28N4O3.HCl |
| MW | 468.6.36.5 |
| MerckIndex | 14:8290 |
| CAS | 169939-93-9 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Redsolid. |
| Solubility | SolubleinDMSO.Slightlysolublein100%ethanolorwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | NYQIEYDJYFVLPO-FERBBOLQSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- IsozymeselectiveinhibitorofproteinkinaseCβ(PKCβ)[1,6,10,11,13].
- PKCβIandPKCβIIisozymeinhibitor[2-3,6,10,11,13].
- Amelioriatesdiabeticretinopathy,diabeticperipheralneuropathyanddiabeticnephropathy[1,3,5-7,9-11].
- Anti-cancerandanti-angiogeniccompound[4-5,8].
- Suppressesglucose-inducedadhesionofhumanmonocytestoendothelialcells[12].
- SuppressesERK1/2andAktphosphorylation[14].
ProductReferences
- AmeliorationofvasculardysfunctionsindiabeticratsbyanoralPKCbetainhibitor:H.Ishii,etal.;Science272,728(1996)
- (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxADIazacyclohexadecene-1,3(2H)-dione(LY333531)andrelatedanalogues:isozymeselectiveinhibitorsofproteinkinase:M.R.Jirousek,etal.;J.Med.Chem.39,2664(1996)
- Vascularendothelialgrowthfactor-inducedretinalpermeabilityismediatedbyproteinkinaseCinvivoandsuppressedbyanorallyeffectivebeta-isoform-selectiveinhibitor:L.P.Aiello,etal.;Diabetes46,1473(1997)
- EnzymaticrationaleandpreclinicalsupportforapotentproteinkinaseCbetainhibitorincancertherapy:B.A.Teicher,etal.;Adv.EnzymeRegul.39,313(1999)
- ProteinkinaseCinthetreatmentofdisease:signaltransductionpathways,inhibitors,andagentsindevelopment:P.G.Goekjian&M.R.Jirousek;Curr.Med.Chem.6,877(1999)
- AproteinkinaseC-beta-selectiveinhibitoramelioratesneuraldysfunctioninstreptozotocin-induceddiabeticrats:J.Nakamura,etal.;Diabetes48,2090(1999)
- AmeliorationofaccelerateddiabeticmesangialexpansionbytreatmentwithaPKCbetainhibitorindiabeticdb/dbmice,arodentmodelfortype2diabetes:D.Koya,etal.;FASEBJ.14,439(2000)
- ProteinkinaseCinhibitorsasnovelanticancerdrugs:P.G.Goekjian&M.R.Jirousek;ExpertOpin.Investig.Drugs10,2117(2001)
- EffectsoftheproteinkinaseCbetainhibitorLY333531onneuralandvascularfunctioninratswithstreptozotocin-induceddiabetes:M.A.Cotter,etal.;Clin.Sci. 103,311(2002)
- Ruboxistaurin,aproteinkinaseCbetainhibitor,asanemergingtreatmentfordiabetesmicrovascularcomplications:S.V.Joy,etal.;Ann.Pharmacother.39,1693(2005)
- Ruboxistaurin:C.A.Taulien&S.V.Joy;DrugsToday42,577(2006)
- Thebeta-specificproteinkinaseCinhibitorruboxistaurin(LY333531)suppressesglucose-inducedadhesionofhumanmonocytestoendothelialcellsinvitro:T.Kunt,etal.;J.DiabetesSci.Technol.1,929(2007)
- ProteinkinaseCisozymesandtheirselectivitytowardsruboxistaurin:S.Tang,etal.;Proteins72,447(2008)
- Ruboxistaurin,aPKCbetainhibitor,inhibitsretinalneovascularizationviasuppressionofphosphorylationofERK1/2andAkt:S.Nakamura,etal.;Exp.EyeRes.90,137(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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