Adipogen/LY-294,002/AG-CR1-0108-M001/1 mg
商品编号：
AG-CR1-0108-M001
品牌：
Adipogen Inc
市场价：
¥600.00
美元价：
360.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |
| ProductType | Chemical |
| Properties | |
| Formula | C19H17NO3 |
| MW | 307.4 |
| CAS | 154447-36-6 |
| PurityChemicals | ≥99%(NMR) |
| Appearance | Whitetooff-whitecrystallinesolid. |
| Solubility | SolubleinDMSO,100%ethanolormethanol. |
| Identity | Determinedby1H-NMR. |
| InChiKey | CZQHHVNHHHRRDU-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potent,cellpermeable,highlyspecific,reversIBLePI(3)K(phosphoinositide3-kinase)inhibitor.
- pan-classI/II/IIIPI3Kinhibitor.
- ActsontheATP-bindingsiteoftheenzyme.
- Insolutionmorestablethanwortmannin.
- AntagonizesP-glycoprotein-mediatedmultidrugresistance.
- BlocksAktphosphorylation.
- Pim-1kinaseinhibitor.
- Autophagyinhibitor(autophagosomeformation).
- InhibitorofBETbromodomain proteinsBRD2,BRD3andBRD4.
ProductReferences
- Aspecificinhibitorofphosphatidylinositol3-kinase,2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one(LY294002):C.J.Vlahos,etal.;J.Biol.Chem.269,5241(1994)
- Investigationofneutrophilsignaltransductionusingaspecificinhibitorofphosphatidylinositol3-kinase:C.J.Vlahos,etal.;J.Immunol.154,2413(1995)
- Pim-1Ligand-boundStructuresRevealtheMechanismofSerine/ThreonineKinaseInhibitionbyLY294002:M.D.Jacobs,etal.;J.Biol.Chem.280,13728(2005)
- LY294002andLY303511SensitizeTumorCellstoDrug-InducedApoptosisviaIntracellularHydrogenPeroxideProductionIndependentofthePhosphoinositide3-Kinase-AktPathway:T.W.Poh&S.Pervaiz;CancerRes.65,6264(2005)
- LY294,002,aspecificinhibitorofPI3K/Aktkinasepathway,antagonizesP-glycoprotein-mediatedmultidrugresistance:M.Barancík,etal.;Eur.J.Pharm.Sci.29,426(2006)
- AroleforAktintherapidregulationofinflammatoryandapoptoticpathwaysinmousebladder:F.J.Tamarkin,etal.;NaunynSchmiedebergsArch.Pharmacol.373,349(2006)
- SynthesisandBIOLOGicalevaluationofsulfonylhydrazone-substitutedimidazo[1,2-a]pyridinesasnovelPI3kinasep110alphainhibitors:M.Hayakawa,etal.;Bioorg.Med.Chem.15,5837(2007)
- ThecommonlyusedPI3-kinaseprobeLY294002isaninhibitorofBETbromodomains:A.Dittmann,etal.;ACSChem.Biol.9,495(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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