Adipogen/Luteolin/AG-CN2-0098-M005/5 mg
商品编号：
AG-CN2-0098-M005
品牌：
Adipogen Inc
市场价：
¥300.00
美元价：
180.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 3",4",5,7-Tetrahydroxyflavone;Luteolol;BRN0292084;C.I.NaturalYellow2;Digitoflavone;Flacitran;Flavopurpol;Daphneflavonol;Argemexitin |
| ProductType | Chemical |
| Properties | |
| Formula | C15H10O6 |
| MW | 286.2 |
| CAS | 491-70-3 |
| RTECS | LK9275210 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Yellowsolid. |
| Solubility | SolubleinDMSO,DMF,methanolorethanol.Slightlysolubleinwater. |
| InChiKey | IQPNAANSBPBGFQ-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Anticancerandantimetastatic[1,3,8].
- α-Glucosidaseinhibitor[2].
- TopoisomeraseIInhibitor[3].
- Apoptosisinducer[7,8].
- Anti-inflammatory[4,5].
- 15-Lipoxygenase(15-LOX)inhibitor[6].
- IL-6productioninhibitor[9].
- Fattyacidsynthase(FAS)inhibitor[10].
- Antioxidant.FreerADIcalscavenger[11].
- AntiAdipogenic.PPAR-γinhibitor[12].
- Neuroprotective.Monoaminetransporteractivator[13].
- Inhibitorofphosphodiesterases1-5(PDE1-5)[14].
- PKC(ε)andSrckinaseinhibitor[15].
- HDACinhibitor[16].
- Autophagymodulator[17]
- Phosphatidylinositol3-kinase(PI3K)/Aktsignalinginhibitor[18].
- p90ribosomalS6kinase(RSK1/RSK2)kinaseactivityinhibitor[19].
ProductReferences
- Effectsofluteolinandquercetin,inhibitorsoftyrosinekinase,oncellgrowthandmetastasis-associatedpropertiesinA431cellsoverexpressingepidermalgrowthfactorreceptor:Y.T.Huang,etal.;Br.J.Pharmacol.128,999(1999)
- Inhibitionofalpha-glucosidaseandamylasebyluteolin,aflavonoid:J.S.Kim,etal.;Biosci.Biotechnol.Biochem.64,2458(2000)
- Luteolin,anemerginganti-cancerflavonoid,poisonseukaryoticDNAtopoisomeraseI:A.R.Chowdhury,etal.;Biochem.J.366,653(2002)
- Inhibitionofmatrix-proteasesbypolyphenols:Chemicalinsightsforanti-inflammatoryandanti-invasiondrugdesign:L.Sartor,etal.;Biochem.Pharmacol.64, 229(2002)
- Luteolininhibitsthenuclearfactor-kappaBtranscriptionalactivityinRat-1fibroblasts:S.H.Kim,etal.;Biochem.Pharmacol.66,955(2003)
- Inhibitionof15-lipoxygenasesbyflavonoids:Structure-activityrelationsandmodeofaction:C.D.Sadik,etal.;Biochem.Pharmacol.65,773(2003)
- InductionofapoptosisbyluteolinthroughcleavageofBcl-2familyinhumanleukemiaHL-60cells:A.C.Cheng,etal.;Eur.J.Pharmacol.509,1(2005)
- Luteolininhibitsinsulin-likegrowthfactor1receptorsignalinginprostatecancercells:J.Fang,etal.;Carcinogenesis28,713(2007)
- LuteolinreducesIL-6productioninmicrogliabyinhibitingJNKphosphorylationandactivationofAP-1:S.Jang,etal.;PNAS105,7534(2008)
- Inhibitionoffattyacidsynthasebyluteolinpost-transcriptionallydown-regulatesc-Metexpressionindependentofproteosomal/lysosomaldegradation:D.T.Coleman,etal.;Mol.CancerTher.8,214(2009)
- Physicochemicalpropertiesandantioxidantactivitiesofluteolin-phospholipidcomplex:K.Xu,etal.;Molecules14,3486(2009)
- LuteolininhibitsadipogenicdifferentiationbyregulatingPPARgammaactivation:H.S.Park,etal.;Biofactors35,373(2009)
- FunctionalactivationofmonoaminetransportersbyluteolinandapigeninisolatedfromthefruitofPerillafrutescens:G.Zhao,etal.;NeuRochem.Int.56,168(2010)
- Luteolin,anon-selectivecompetitiveinhibitorofphosphodiesterases1-5,displaced[3H]-rolipramfromhigh-affinityroliprambindingsitesandreversedxylazine/ketamine-inducedanesthesia:M.C.Yu,etal.;Pulmon.Gastrointest.Urogen.Pharmacol.627,269(2010)
- LuteolininhibitsproteinkinaseC(epsilon)andc-SrcactivitiesandUVB-inducedskincancer:S.Byun,etal.;CancerRes.70,2415(2010)
- Inhibitionofcellsurvival,invasion,tumorgrowthandhistonedeacetylaseactivitybythedietaryflavonoidluteolininhumanepithelioidcancercells:S.Attoub,etal.;Eur.J.Pharmacol.651,18(2011)
- Autophagyinhibitorchloroquineenhancedthecelldeathinducingeffectoftheflavonoidluteolininmetastaticsquamouscellcarcinomacells:L.Verschooten,etal.;PLoSOne7,e48264
- RafandPI3Karethemoleculartargetsfortheanti-metastaticeffectofLuteolin:H.Y.Kim,etal.;Phytother.Res.27,1481(2013)
- Luteolinisanovelp90ribosomalS6kinase(RSK)inhibitorthatsuppressesNotch4signalingbyblockingtheactivationofY-boxbindingprotein-1(YB-1):K.M.Reipas,etal.;Oncotarget4,329(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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