脂肪原/洛索里滨/AG-CR1-3584-M025/25毫克
商品编号：
AG-CR1-3584-M025
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 7-Allyl-8-oxoguanosine;RWJ21757 |
| ProductType | Chemical |
| Properties | |
| Formula | C13H17N5O6 |
| MW | 339.3 |
| CAS | 121288-39-9 |
| PurityChemicals | ≥97% |
| Appearance | Whitetooff-whitepowder. |
| Solubility | SolubleinDMSO(30mg/ml)orwater(10mg/ml). |
| InChiKey | VDCRFBBZFHHYGT-HKPXRNTQDL |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Stocksolutionsarestableforatleast3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- GuanosineanalogderivatizedatpositionN7andC8[1].
- Verypotentimmunostimulatorycompoundthatincreasescytokineproduction[2-5].
- Antitumorandantiviralactivitycompound[5,6,7,12].
- PotentandselectivesyntheticligandforToll-likereceptor7(TLR7)[7-10].
- Co-incubationwiththymidinehomopolymeroligodeoxynucleotides(ODN)redirectedthestimulatoryeffectofloxoribineawayfromTLR7towardTLR8[11].
- Inducesautophagyandautophagy-inducedcelldeathinCaco-2cells[12].
- Showsadjuvantactivitytoincreasetheeffectivenessofvaccines[4].
ProductReferences
- SubstitutedguanineribonucleosidesasBcellactivators:S.Gupta,etal.;Clin.Immunol.Immunopathol.61,21(1991)
- Invivoenhancementofmurinenaturalkillercellactivityby7-allyl-8-oxoguanosine(loxoribine):B.L.Pope,etal.;Int.J.Immunopharmacol.14,1375(1992)
- Loxoribine(7-allyl-8-oxoguanosine)activatesnaturalkillercellsandprimescytolyticprecursorcellsforactivationbyIL-2:B.L.Pope,etal.;J.Immunol.151,3007(1993)
- 7-Allyl-8-oxoguanosine(loxoribine)inhibitsthemetastasisofB16melanomacellsandhasadjuvantactivityinmiceimmunizedwithaB16tumorvaccine: B.L.Pope,etal.;CancerImmunol.Immunother.38,83(1994)
- Theimmunostimulatorycompound7-allyl-8-oxoguanosine(loxoribine)inducesadistinctsubsetofmurinecytokines:B.L.Pope,etal.;CellImmunol.162,333(1995)
- Phase1,randomized,double-blindtrialof7-allyl-8-oxoguanosine(loxoribine)inadvancedcancer:S.S.Agarwala,etal.;CytokinesCellMol.Ther.6,171(2000)
- Recognitionofpathogen-associatedmolecularpatternsbyTLRfamily:S.Akira&H.Hemmi;Immunol.Lett.85,85(2003)(Review)
- TheToll-likereceptor7(TLR7)-specificstimulusloxoribineuncoversastrongrelationshipwithintheTLR7,8and9subfamily:F.Heil,etal.;Eur.J.Immunol.33,2987(2003)
- SyntheticTLRagoNISTsrevealfunctionaldifferencesbetweenhumanTLR7andTLR8:K.B.Gorden,etal.;J.Immunol.174,1259(2005)
- InterventionofToll-likereceptor-mediatedhumaninnateimmunityandinflammationbysyntheticcompoundsandnaturallyoccurringproducts:S.Fasciano&L.Li;Curr.Med.Chem.13,1389(2006)(Review)
- ModulatingresponsivenessofhumanTLR7and8tosmallmoleculeligandswithT-richphosphorothiateoligodeoxynucleotides:M.Jurk,etal.;Eur.J.Immunol.36,1815(2006)
- Autophagy-mediatedanti-tumoralactivityofimiquimodinCaco-2cells:J.Y.Yi,etal.;BBRC386,455(2009)
- Loxoribine,aselectiveToll-likereceptor7agonist,inducesmaturationofhumanmonocyte-deriveddendriticcellsandstimulatestheirTh-1-andTh-17-polarizingcapability:T.Dzopalic,etal.;Int.Immunopharmacol.10,1428(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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