Adipogen/Lovastatin/AG-CN2-0051-M025/25 mg
商品编号：
AG-CN2-0051-M025
品牌：
Adipogen Inc
市场价：
¥1000.00
美元价：
600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Mevilonin;MK-803;6-α-Methylcompactin;BRN3631989 |
| ProductType | Chemical |
| Properties | |
| Formula | C24H36O5 |
| MW | 404.6 |
| MerckIndex | 14:5586 |
| CAS | 75330-75-5 |
| RTECS | EK7907000 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO,ethanolormethanol.Insolubleinwater. |
| Identity | DeterminedbyUVandIR. |
| InChiKey | PCZOHLXUXFIOCF-BXMDZJJMSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Statincompound.
- PotentcompetitiveHMG-CoAreductaseinhibitor[1].
- Anti-hypercholesterolemicagent[1].
- Cholesterol/isoprenoidbiosynthesisinhibitor.Blockstheproductionofmevalonate,acriticalcompoundintheproductionofcholesterolandisoprenoids[1,2].
- InhibitstheisoprenylationofRasandRhofamilyGTPases[2].
- CausescellcyclearrestinG1andG2/Mphasesthroughmodulationofproteasomeincancercelllines[3,5,7].
- Smoothmusclecellproliferationinhibitor[4].
- Apoptosisinducer[5,11].
- Anticancercompound[5,11,12].
- Anti-adhesive,immunomodulatoryandanti-inflammatorycompound[6,10,13,15].
- Stimulates boneformation[8].
- Increasescellularresistancetoanticanceragentssuchasdoxorubicinandetoposide(Prod.No.AG-CR1-3572)[9].
- SuppressesICAM-1-LFA-1interactions,whichblocksvirusreplicationandinfection[14,15].
- Anti-hypertensiveagent[16].
- SuppressesTNF-inducedNF-κBactivation[17].
- Modulateskeycell signaling pathways,likeRas, MAPKandEGFR(modest)[18].
ProductReferences
- Mevinolin:ahighlypotentcompetitiveinhibitorofhydroxymethylglutaryl-coenzymeAreductaseandacholesterol-loweringagent:A.W.Alberts,etal.;PNAS77,3957(1980)
- Allrasproteinsarepolyisoprenylatedbutonlysomearepalmitoylated:J.F.Hancock,etal.;Cell57,1167(1989)
- Cellcycle-specificeffectsoflovastatin:M.Jakobisiak,etal.;PNAS88,3628(1991)
- InhibitionofproliferationofhumansmoothmusclecellsbyvariousHMG-CoAreductaseinhibitors;comparisonwithotherhumancelltypes:P.Negre-Aminou,etal.;Biochim.Biophys.Acta1345,259(1997)
- Lovastatin-inducedinhibitionofHL-60cellproliferationviacellcyclearrestandapoptosis:W.H.Park,etal.;AnticancerRes.19,3133(1999)
- Statinsasanewlyrecognizedtypeofimmunomodulator:B.Kwak,etal.;Nat.Med.6,1399(2000)
- Lovastatinandsimvastatinaremodulatorsoftheproteasome:C.Wojcik,etal.;Int.J.Biochem.CellBiol.32,957(2000)
- Statinsandboneformation:I.R.Garrett,etal.;Curr.Pharm.Des.7,715(2001)
- TheHMG-CoAreductaseinhibitorlovastatinprotectscellsfromtheantineoplasticdrugsdoxorubicinandetoposide:R.V.Bardeleben,etal.;Int.J.Mol.Med.10,473(2002)
- HMG-CoAreductaseinhibitorsasimmunomodulators:potentialuseintransplantrejection:L.J.Raggatt&N.C.Partridge;Drugs62,2185(2002)(Review)
- HMG-CoAreductaseinhibitorsandthemalignantcell:thestatinfamilyofdrugsastriggersoftumor-specificapoptosis:W.W.Wong,etal.;Leukemia16,508(2002)
- Thestatinsasanticanceragents:K.K.Chan,etal.;Clin.CancerRes.9,10(2003)
- Anti-inflammatoryandimmunomodulatoryeffectsofstatins:L.M.Blanco-Colio,etal.;KidneyInt.63,12(2003)
- Statincompoundsreducehumanimmunodeficiencyvirustype1replicationbypreventingtheinteractionbetweenvirion-associatedhostintercellularadhesionmolecule1anditsnaturalcellsurfaceligandLFA-1:J.F.Giguere&M.J.Tremblay;J.Virol.78,12062(2004)
- HMGCoAreductaseinhibitors(statins)totreatEpstein-Barrvirus-drivenlymphoma:J.I.Cohen;Br.J.Cancer92,1593(2005)
- Beyondlipidlowering:theanti-hypertensiveroleofstatins:V.Chopra,etal.;Cardiovasc.DrugsTher.21,161(2007)
- Reversalofchemoresistanceandenhancementofapoptosisbystatinsthroughdown-regulationoftheNF-κBpathway:K.S.Ahn,etal.;Biochem.Pharmacol.75,907(2008)
- TherapeuticLevelsOfTheHydroxmethylglutaryl-CoenzymeAReductaseInhibitorLovastatinActivateRasSignalingViaPhospholipaseD2:K.J.Cho,etal.;Mol.Cell.Biol.31,1110(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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