Adipogen/Linagliptin/AG-CR1-3618-M050/50 mg
商品编号：
AG-CR1-3618-M050
品牌：
Adipogen Inc
市场价：
¥2400.00
美元价：
1440.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione;BI-1356 |
| ProductType | Chemical |
| Properties | |
| Formula | C25H28N8O2 |
| MW | 472.5 |
| CAS | 668270-12-0 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO(5mg/ml),ethanolormethanol.Slightlysolubleinwater(~1mg/ml). |
| InChiKey | LTXREWYXXSTFRX-QGZVFWFLSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antidiabeticagent.
- Highlypotentandselectivecompetitiveinhibitorofdipeptidyl-peptidase4(DPP4;DPPIV;CD26),anenzymethatdegrades,glucagon-likepeptide-1(GLP-1)andglucose-dependentinsulinotropicpolypeptide(GIP).PreventstheinactivationofendogenousGLP-1andGIP.
- ShowntorestoreβcellfunctionandsurvivalinhumanisolatedisletsthroughGLP-1stabilization.
- Improvesinsulinsensitivity.
- Anti-inflammatorycompound.
ProductReferences
- 8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione(BI1356),ahighlypotent,selective,long-acting,andorallybioavailableDPP-4inhibitorforthetreatmentoftype2diabetes:M.Eckhardt,etal.;J.Med.Chem.50,6450(2007)
- Safety,tolerability,pharmacokinetics,andpharmacodynamicsofsingleoraldosesofBI1356,aninhibitorofdipeptidylpeptidase4,inhealthymalevolunteers:S.Hüttner,etal.;J.Clin.Pharmacol.48,1171(2008)
- (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione(BI1356),anovelxanthine-baseddipeptidylpeptidase4inhibitor,hasasuperiorpotencyandlongerdurationofactioncomparedwithotherdipeptidylpeptidase-4inhibitors:L. Thomas,etal.;J.Pharmacol.Exp.Ther.325,175(2008)
- Pharmacokinetics,pharmacodynamicsandtolerabilityofmultipleoraldosesoflinagliptin,adipeptidylpeptidase-4inhibitorinmaletype2diabetespatients:T.Heise,etal.;DiabetesObes.Metab.11,786(2009)
- TheDPP4inhibitorlinagliptindelaystheonsetofdiabetesandpreservesβ-cellmassinnon-obesediabeticmice:J.Jelsing,etal.;J.Endocrinol.214,381(2012)
- Thedipeptidylpeptidase-4inhibitorlinagliptinattenuatesinflammationandacceleratesepithelializationinwoundsofdiabeticob/obmice:C.Schurmann,etal.;J.Pharmacol.Exp.Ther.342,71(2012)
- Linagliptinimprovesinsulinsensitivityandhepaticsteatosisindiet-inducedobesity:M.Kern,etal.;PLoSOne7,e38744(2012)
- EmergingDPP-4inhibitors:focusonlinagliptinfortype2diabetes:B.Gallwitz;DiabetesMetab.Syndr.Obes.6,1(2013)(Review)
- TheDPP-4inhibitorlinagliptinrestoresβ-cellfunctionandsurvivalinhumanisolatedisletsthroughGLP-1stabilization:P.Shah,etal.;J.Clin.Endocrinol.Metab.98,E1163(2013)
- Linagliptin:frombenchtobedside:J.Doupis;Drug.Des.Devel.Ther.8,431(2014)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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