Adipogen/Leupeptin . hemisulfate/AG-CP3-7000-M100/100 mg
商品编号：
AG-CP3-7000-M100
品牌：
Adipogen Inc
市场价：
¥5400.00
美元价：
3240.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Acetyl-L-leucyl-L-leucyl-L-argininal.hemisulfate |
| ProductType | Chemical |
| Properties | |
| Formula | C20H38N6O4.0.5H2SO4 |
| MW | 426.6.49.0 |
| Sequence | Ac-Leu-Leu-Arginal |
| MerckIndex | 14:5456 |
| CAS | 103476-89-7 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥97%(HPLC) |
| Appearance | Whitetooff-whitepowder. |
| Solubility | Solubleinethanol,methanolorwater. |
| OtherProductData | LeupeptingivesmultiplepeaksonHPLCduetoequilibriaamongthreeformsinsolution.Puritydeterminedusingthreemainpeaks.Majorityofcontaminatingpeptideisracemizedleupeptin. |
| InChiKey | CIPMKIHUGVGQTG-VFFZMTJFSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potent,competitiveandreversIBLecysteine,serineandthreonineproteaseinhibitor.Inhibitscalpain,kallikrein,trypsin,plasmin,papainandcathepsinB.
- Doesnotinhibitpepsin,elastase,renin,cathepsinsAandD,thrombinorα-chymotrypsin.
- Usedtoprotectagainsthearinglosscausedbyacousticoverstimulationortheototoxicantibioticgentamicin.
- Showntoinhibitactivation-inducedprogrammedcelldeath.
- Antioxidantandanti-inflammatoryagent.
- WidelyusedasaproteinpurificationtooltopreventproteasespresentintissuesamplesfromdegrADIngtheproteinofinterest.
ProductReferences
- Leupeptins,newproteaseinhibitorsfromactinomycetes:T.Aoyagi,etal.;J.Antibiot.(Tokyo)22,283(1969)
- BIOLOGicalactivitiesofleupeptins:T.Aoyagi;J.Antibiot.(Tokyo)22,558(1969)
- Mechanismofassociationofaspecificaldehydeinhibitor,leupeptin,withbovinetrypsin:H.Kuramochi,etal.;J.Biochem.86,1403(1979)
- Theslow,tight-bindinginhibitionofcathepsinBbyleupeptin.Ahystereticeffect:A.Baici,etal.;Eur.J.Biochem.129,33(1982)
- Leupeptin,athiolproteinaseinhibitor,causesaselectiveimpairmentofspatialmazeperformanceinrats:U.Staubli,etal.;Behav.Neural.Biol.40,58(1984)
- Leupeptinselectivelyinhibitshumanplateletresponsesinducedbythrombinandtrypsin;aroleforproteolyticactivationofphospholipaseC:M.Ruggiero&E.G.Lapetina;BBRC131,1198(1985)
- Protease-inhibitoryactivitiesofleupeptinanalogues:T.Saino,etal.;J.Antibiot.(Tokyo)41,220(1988)
- Newleupeptinanalogues:synthesisandinhibitiondata:R.M.McConnell,etal.;J.Med.Chem.33,86(1990)
- Developingselectiveinhibitorsofcalpain:K.K.Wang,etal.;TIPS11,139(1990)
- Cell-penetratinginhibitorsofcalpain:S.Mehdi,etal.;TIBS16,150(1991)
- Inhibitionstudiesofsomeserineandthiolproteinasesbynewleupeptinanalogues:R.M.McConnell,etal.;J.Med.Chem.36,1084(1993)
- Inhibitionofactivation-inducedprogrammedcelldeathandrestorationofdefectiveimmuneresponsesofHIV+donorsbycysteineproteaseinhibitors:A.Sarin,etal.;J.Immunol.153,862(1994)
- Inhibitionofmuanddeltaopioidreceptorligandbindingbythepeptidealdehydeproteaseinhibitor,leupeptin:K.H.Christoffers,etal.;Regul.Pept.105,9(2002)
- Invitroantioxidantpropertiesofcalpaininhibitors:leupeptinandcalpaininhibitor-1:C.Perrin,etal.;Cell.Mol.Biol.(Noisy-le-grand)48,OL267(2002)
- InhibitorsofcathepsinB:F.Frlan&S.Gobec;Curr.Med.Chem.13,2309(2006)
- Leupeptin,acalpaininhibitor,protectsinnerearhaircellsfromaminoglycosideototoxicity:J.Momiyama,etal.;TohokuJ.Exp.Med.209,89(2006)
- Leupeptinreducesimpulsenoiseinducedhearingloss:H.Gavriel,etal.;J.Occup.Med.Toxicol.6,38(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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