Adipogen/Leupeptin . hemisulfate/AG-CP3-7000-M005/5 mg
商品编号：
AG-CP3-7000-M005
品牌：
Adipogen Inc
市场价：
¥700.00
美元价：
420.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Acetyl-L-leucyl-L-leucyl-L-argininal . hemisulfate |
| Product Type | Chemical |
| Properties | |
| Formula | C20H38N6O4 . 0.5 H2SO4 |
| MW | 426.6 . 49.0 |
| Sequence | Ac-Leu-Leu-Arginal |
| Merck Index | 14: 5456 |
| CAS | 103476-89-7 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in ethanol, methanol or water. |
| Other Product Data |
Leupeptin gives multiple peaks on HPLC due to equilibria among three forms in solution. Purity determined using three main peaks. Majority of contaminating peptide is racemized leupeptin. |
| InChi Key | CIPMKIHUGVGQTG-VFFZMTJFSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Potent, competitive and reversible cysteine, serine and threonine protease inhibitor. Inhibits calpain, kallikrein, trypsin, plasmin, papain and cathepsin B.
- Does not inhibit pepsin, elastase, renin, cathepsins A and D, thrombin or α-chymotrypsin.
- Used to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin.
- Shown to inhibit activation-induced programmed cell death.
- Antioxidant and anti-inflammatory agent.
- Widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.
Product References
- Leupeptins, new protease inhibitors from actinomycetes: T. Aoyagi, et al.; J. Antibiot. (Tokyo) 22, 283 (1969)
- Biological activities of leupeptins: T. Aoyagi; J. Antibiot. (Tokyo) 22, 558 (1969)
- Mechanism of association of a specific aldehyde inhibitor, leupeptin, with bovine trypsin: H. Kuramochi, et al.; J. Biochem. 86, 1403 (1979)
- The slow, tight-binding inhibition of cathepsin B by leupeptin. A hysteretic effect: A. Baici, et al.; Eur. J. Biochem. 129, 33 (1982)
- Leupeptin, a thiol proteinase inhibitor, causes a selective impairment of spatial maze performance in rats: U. Staubli, et al.; Behav. Neural. Biol. 40, 58 (1984)
- Leupeptin selectively inhibits human platelet responses induced by thrombin and trypsin; a role for proteolytic activation of phospholipase C: M. Ruggiero & E.G. Lapetina; BBRC 131, 1198 (1985)
- Protease-inhibitory activities of leupeptin analogues: T. Saino, et al.; J. Antibiot. (Tokyo) 41, 220 (1988)
- New leupeptin analogues: synthesis and inhibition data: R.M. McConnell, et al.; J. Med. Chem. 33, 86 (1990)
- Developing selective inhibitors of calpain: K.K. Wang, et al.; TIPS 11, 139 (1990)
- Cell-penetrating inhibitors of calpain: S. Mehdi, et al.; TIBS 16, 150 (1991)
- Inhibition studies of some serine and thiol proteinases by new leupeptin analogues: R.M. McConnell, et al.; J. Med. Chem. 36, 1084 (1993)
- Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors: A. Sarin, et al.; J. Immunol. 153, 862 (1994)
- Inhibition of mu and delta opioid receptor ligand binding by the peptide aldehyde protease inhibitor, leupeptin: K.H. Christoffers, et al.; Regul. Pept. 105, 9 (2002)
- In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1: C. Perrin, et al.; Cell. Mol. Biol. (Noisy-le-grand) 48, OL267 (2002)
- Inhibitors of cathepsin B: F. Frlan & S. Gobec; Curr. Med. Chem. 13, 2309 (2006)
- Leupeptin, a calpain inhibitor, protects inner ear hair cells from aminoglycoside ototoxicity: J. Momiyama, et al.; Tohoku J. Exp. Med. 209, 89 (2006)
- Leupeptin reduces impulse noise induced hearing loss: H. Gavriel, et al.; J. Occup. Med. Toxicol. 6, 38 (2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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