Adipogen/Leucettine L41/AG-MR-C0023-M005/5 mg
商品编号：
AG-MR-C0023-M005
品牌：
Adipogen Inc
市场价：
¥4000.00
美元价：
2400.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (5Z)-5-(1,3-Benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4one |
| ProductType | Chemical |
| Properties | |
| Formula | C17H13N3O3 |
| MW | 307.3 |
| CAS | 1112978-84-3 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Beigesolid. |
| Solubility | SolubleinDMSOorethanol. |
| Reconstitution | Stocksolutionscanbemadeupto10mMinDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | PGPHHJBZEGSUNE-JYRVWZFOSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentinhibitorofDYRKs(DYRK1A(IC50=40nM);DYRK2(IC50=35nM))andCLKs(CLK1,CLK3).InteractsalsowithGSK-3α/β,CK2andPIM1.
- InteractswiththecomplexPIKfyve/Vac14/Fig4.
- Modulatesalternativesplicingofpre-mRNAinvariouscellularsystems.
- NeuroprotectiveagainstAPP-inducedcelldeath.
- Toolstostudyandmodulatepre-RNAsplicing.PotentialcompoundforAlzheimer"sdiseaseanddiseasesinvolvingabnormalpre-mRNAsplicing.
- PotentialcompoundtostudyDownsyndrome(inhibitionofDYRK1A).
- Neuroprotectiveagainstglutamate-inducedcelldeath.
- Autophagyactivator.
ProductReferences
- Leucettines,aclassofpotentinhibitorsofcdc2-likekinasesanddualspecificity,tyrosinephosphorylationregulatedkinasesderivedfromthemarinespongeLeucettamineB:modulationofalternativepre-RNAsplicing:M.DeBDab,etal.;J.Med.Chem.54,4172(2011)
- Selectivity,cocrystalstructures,andneuroprotectivepropertiesofleucettines,afamilyofproteinkinaseinhibitorsderivedfromthemarinespongealkaloidleucettamineB:T.Tahtouh,etal.;J.Med.Chem.55,9312(2012)
- Leucettines,afamilyofpharmacologicalinhibitorsofDYRKs&CLKskinasesderivedfromthemarinespongeLeucettamineB:T.Tahtouh,etal.;PlantaMed.78,(2012)
- ChemicalsynthesisandBIOLOGicalvalidationofimmobilizedproteinkinaseinhibitoryLeucettines:G.Burgy,etal.;Eur.J.Med.Chem.62,728(2013)
- Cdc-like/dual-specificitytyrosinephosphorylation-regulatedkinasesinhibitorleucettineL41inducesmTOR-dependentautophagy:implicationforAlzheimer"sdisease:X.Fant,etal.;Mol.Pharmacol.85,441(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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