Adipogen/LEE011/SYN-1213-M005/5 mg
商品编号：
SYN-1213-M005
品牌：
Adipogen Inc
市场价：
¥1720.00
美元价：
1032.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | LEE-011;Ribociclib |
| ProductType | Chemical |
| Properties | |
| Formula | C23H30N8O |
| MW | 434.5 |
| CAS | 1211441-98-3 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:CDK4/CDK6|KinaseGroup:CGMC|Substrate:Serine-Threonine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | RHXHGRAEPCAFML-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Orallyavailablecyclin-dependentkinase(CDK)inhibitortargetingcyclinD1/CDK4andcyclinD3/CDK6cellcyclepathways,withpotentialantineoplasticactivity.SpecificallyinhibitsCDK4and6,therebyinhibitingretinoblastoma(Rb)proteinphosphorylation.InhibitionofRbphosphorylationpreventsCDK-mediatedG1-Sphasetransition,therebyarrestingthecellcycleintheG1phase,suppressingDNAsynthesisandinhibitingcancercellgrowth.OverexpressionofCDK4/6,asseenincertaintypesofcancer,causescellcyclederegulation.
ProductReferences
- DualCDK4/CDK6inhibitioninducescell-cyclearrestandsenescenceinneuroblastoma:J.Rader,etal.;Clin.CancerRes.19,6173(2013)
- Molecularpathways:CDK4inhibitorsforcancertherapy:M.A.Dickson;Clin.CancerRes.20,3379(2014)
- AntiproliferativeeffectsofCDK4/6inhibitioninCDK4-amplifiedhumanliposarcomainvitroandinvivo:Y.X.Zhang,etal.;Mol.CancerTher.13,2184(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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