Adipogen/Lactacystin/AG-CN2-0104-M001/1 mg
商品编号：
AG-CN2-0104-M001
品牌：
Adipogen Inc
市场价：
¥10600.00
美元价：
6360.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| ProductType | Chemical |
| Properties | |
| Formula | C15H24N2O7S |
| MW | 376.4 |
| CAS | 133343-34-7 |
| Source/HostChemicals | IsolatedfromStreptomyceslactacystinnaeusstrainOM-6519. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solubleinwater,methanol,ethanol,DMSO,pyridine,acetonitrileordimethylformamide.Insolubleinhexane,benzene,chloroformorethylacetate. |
| Declaration | ManufacturedbyBiOlinksK.K.withcourtesystrainfromTheKitasatoInstitute. |
| InChiKey | DAQAKHDKYAWHCG-MJZHQVMOSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Inducesneuritogenesis[1,3].
- PotentandselectiveirreversIBLeproteasomeinhibitor.Specificallyinhibits20Sproteasome(MCP;multicatalyticcomplex)[2,4,7].Blocksproteasomeactivitybytargetingthecatalyticβ-subunit[5].
- Apoptosisinducer[4,6,7,10].
- Anticancercompound[6,10,13].
- UpregulatesHSP70andHSP22[8].
- Inducesdifferentiationandinhibitscellcycleprogressioninseveraltumorcelllines[9].
- InhibitsNF-κBactivationbyinhibitingIκBdegradation[11].
- CathepsinAinhibitor[12].
- β-Secretaseactivityinhibitor[14].
- Anti-ADIpogenic[15,16].
- Autophagyinducer[17].
ProductReferences
- Lactacystin,anovelmicrobialmetabolite,inducesneuritogenesisofneuroblastomacells:S.Omura,etal.;J.Antibiot.(Tokyo)44,113(1991)
- Inhibitionofproteasomeactivitiesandsubunit-specificamino-terminalthreoninemodificationbylactacystin:G.Fenteany,etal.;Science268,726(1995)
- Structure-activityrelationshipsoflactacystin,thefirstnon-proteinneurotrophicfactor:T.Nagamitsu,etal.;J.Antibiot.(Tokyo)48,747(1995)
- Lactacystin,aspecificinhibitoroftheproteasome,inducesapoptosisinhumanmonoblastU937cells:S.Imajoh-Ohmi,etal.;BBRC217,1070(1995)
- Lactacystinandclasto-lactacystinbeta-lactonemodifymultipleproteasomebeta-subunitsandinhibitintracellularproteindegradationandmajorhistocompatibilitycomplexclassIantigenpresentation:A.Craiu,etal.;J.Biol.Chem.272,56(1997)
- Theproteasomeinhibitorlactacystininducesapoptosisandsensitizeschemo-andradioresistanthumanchroniclymphocyticleukaemialymphocytestoTNF-alpha-initiatedapoptosis:J.Delic,etal.;Br.J.Cancer77,1103(1998)
- Lactacystin,proteasomefunction,andcellfate:G.Fenteany&S.L.Schreiber;J.Biol.Chem.273,8545(1998)(Review)
- ProteasomeinhibitorsMG132andlactacystinhyperphosphorylateHSF1andinducehsp70andhsp27expression:D.Kim,etal.;BBRC254,264(1999)
- InductionofG1arrestandselectivegrowthinhibitionbylactacystininhumanumbilicalveinendothelialcells:S.I.Kumeda,etal.;AnticancerRes.19,3961(1999)
- LactacystinactivatesFLICE(caspase8)proteaseandinducesapoptosisinFas-resistantadultT-cellleukemiacelllines:Y.Yamada,etal.;Eur.J.Haematol.64,315(2000)
- Inhibitoryandstimulatoryeffectsoflactacystinonexpressionofnitricoxidesynthasetype2inbrainglialcells.TheroleofIkappaB-beta:M.Stasiolek,etal.;J.Biol.Chem.275,24847(2000)
- LactacystininhibitscathepsinAactivityinmelanomacelllines:L.Kozlowski,etal.;TumourBiol.22,211(2001)
- Lactacystinexhibitspotentanti-tumoractivityinananimalmodelofmalignantgliomawhenadmiNISTeredviacontrolled-releasepolymers:F.G.Legnani,etal.;J.Neurooncol.77,225(2006)
- Lactacystindecreasesamyloid-betapeptideproductionbyinhibitingbeta-secretaseactivity:P.Kienlen-Campard,etal.;J.Neurosci.Res.84,1311(2006)
- Lactacystininhibits3T3-L1adipocytedifferentiationthroughinductionofCHOP-10expression:X.Li,etal.;BBRC350,1(2006)
- InhibitionofhumanpreadipocyteproteasomalactivitybyHIVproteaseinhibitorsorspecificinhibitorlactacystinleadstoadefectinadipogenesis,whichinvolvesmatrixmetalloproteinase-9:S.DeBarros,etal.;J.Pharmacol.Exp.Ther.320,291(2007)
- Mechanismsofcross-talkbetweentheubiquitin-proteasomeandautophagy-lysosomesystems:V.I.Korolchuk,etal.;FEBSLett.584,1393(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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