Adipogen/L-NMMA . monoacetate/AG-CR1-3578-M025/25 mg
商品编号：
AG-CR1-3578-M025
品牌：
Adipogen Inc
市场价：
¥1100.00
美元价：
660.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NG-Monomethyl-L-arginine.monoacetate |
| ProductType | Chemical |
| Properties | |
| Formula | C7H16N4O2.CH3COOH |
| MW | 188.2.60.1 |
| MerckIndex | 14:6022 |
| CAS | 53308-83-1 |
| RTECS | RM2982000 |
| PurityChemicals | ≥99%(TLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solubleinwater,ethanol,methanolorDMSO. |
| InChiKey | IKPNWIGTWUZCKM-JEDNCBNOBD |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Endothelium-derivedrelaxingfactorinhibitor.InhibitsthegenerationofNOfromarginine.
- Competitive,irreversIBLenon-selectiveinhibitorofallthreeNOSI,II,andIIIisoforms(eNOS,iNOSandnNOS).
- Inhibitsthesynthesisofnitricoxide(NO)inadose-dependentandenantiospecificfashion.
- UsefultooltostudytheroleandtheeffectsofNOincardiovascularandgastrointestinaldisorders,hypertension,diabetes,septicshock,inflammation,infection,strokeandneurodegenerativedisorders.
ProductReferences
- Identificationofarginineasaprecursorofendothelium-derivedrelaxingfactor:I.Sakuma,etal.;PNAS85,8664(1988)
- NG-methylarginine,aninhibitorofendothelium-derivednitricoxidesynthesis,isapotentpressoragentintheguineapig:doesnitricoxideregulatebloodpressureinvivo?:K.Aisaka,etal.;BBRC160,881(1989)
- AspecificinhibitorofnitricoxideformationfromL-arginineattenuatesendothelium-dependentrelaxation:D.D.Rees,etal.;Br.J.Pharmacol.96,418(1989)
- Characterizationofthreeinhibitorsofendothelialnitricoxidesynthaseinvitroandinvivo:D.D.Rees,etal.;Br.J.Pharmacol.101,746(1990)
- Roleofendothelium-formednitricoxideonvascularresponses:J.MarinJ&C.F.Sanchez-Ferrer;Gen.Pharmacol.21,575(1990)
- InactivationofmacrophagenitricoxidesynthaseactivitybyN(G)-methyl-L-arginine:N.M.Olken,etal.;BBRC177,828(1991)
- Nitricoxide:anendogenousmodulatorofleukocyteadhesion:P.Kubes,etal.;PNAS88,4651(1991)
- Macrophagenitricoxidemediatesimmunosuppressionininfectiousinflammation:T.K.Eisenstein,etal.;ImmunoBIOLOGy191,493(1994)(Review)
- N-nitro-L-arginineandN-monomethyl-L-arginineexhibitadifferentialpatternofinactivationtowardthethreenitricoxidesynthases:D.W.Reif&C.A.McCreedy;Arch.Biochem.Biophys.320,170(1995)
- Celldeath,survivalandproliferationinTetrahymenaThermophila.Effectsofinsulin,sodiumnitroprusside,8-BromocyclicGMP,NG-methyl-L-arginineandmethyleneblue:S.T.Christensen;CellBiol.Int.20,653(1996)(Review)
- Nitricoxidesynthaseinhibitors:Aminoacids.O.W.Griffith&R.G.Kilbourn;MethodsEnzymol.268,375(1996)
- Selectiveinhibitorsofneuronalnitricoxidesynthase-isnoNOSreallygoodNOSforthenervoussystem?P.K.Moore&R.L.Handy;TIPS18,204(1997)(Review)
- Asymmetricdimethylarginine(ADMA)andotherendogenousnitricoxidesynthase(NOS)inhibitorsasanimportantcauseofvascularinsulinresistance:K.Toutouzas;Horm.Metab.Res.40,655(2008)(Review)
- InsulinresistanceafterhypertensioninducedbythenitricoxidesynthesisinhibitorL-NMMAinrats:A.D.Baron;Am.J.Physiol.269,E709(1995)
- TheNOsynthaseinhibitorsL-NameandL-NMMA,butnotL-arginine,blockthemammaliannicotinicacetylcholinereceptorchannel:MScheller;Toxicol.Lett.100-101,109(1998)
- InductionofapoptosisbyL-NMMA,viaFKHRL1/ROCKpathwayinhumangastriccancercells:Y.Z.Wang&Z.Q.Feng;Biomed.Environ.Sci.19,285(2006)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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