Adipogen/KU-55933/SYN-1051-M010/10 mg
商品编号：
SYN-1051-M010
品牌：
Adipogen Inc
市场价：
¥2600.00
美元价：
1560.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | KU55933 |
| Product Type | Chemical |
| Properties | |
| Formula | C21H17NO3S2 |
| MW | 395.5 |
| CAS | 587871-26-9 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: ATM/ATR | Kinase Group: Atypical (PIKK) | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | XRKYMMUGXMWDAO-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
KU55933 is a potent and selective ATP-competitive inhibitor of ATM, with an IC(50) of 13nM and a Ki of 2.2nM. KU55933 has potential for use as a new radio- and chemo-sensitizing agent for the treatment of cancer.
Product References
- Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM: I. Hickson, et al.; Cancer Res. 64, 9152 (2004)
- Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis: J.S. Eaton|et al.; J. Clin. Invest. 117, 2723 (2007)
- Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy: E. Crescenzi, et al.; Clin. Cancer Res. 14, 1877 (2008)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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