Adipogen/KN-93 (water soluble)/AG-CR1-0065-M005/5 mg
商品编号：
AG-CR1-0065-M005
品牌：
Adipogen Inc
市场价：
¥2200.00
美元价：
1320.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine |
| ProductType | Chemical |
| Properties | |
| Formula | C26H29ClN2O4S.H3PO4 |
| MW | 501.0.98.0 |
| CAS | 1188890-41-6|139298-40-1(freebase) |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solubleinwater. |
| OtherProductData | Stocksolutionsarestableforupto3monthswhenstoredat-20°C. |
| InChiKey | LHFKHAVGGJJQFF-UEOYEZOQSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Hygroscopic. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- SelectiveCa2+/calmodulin-dependentproteinkinaseIIinhibitor[1].
- Insulinreleaseinhibitor[2].
- Acidsecretioninhibitor[3].
- G1cellcyclearrestinducer[4].
- Apoptosisinducer[4,7].
- Ionchannelinhibitor[5,6].
- ROSinducer[7].
- Androgenreceptorinhibitor[7].
ProductReferences
- ThenewlysynthesizedselectiveCa2+/calmodulindependentproteinkinaseIIinhibitorKN-93reducesdopaminecontentsinPC12hcells:M.Sumi,etal.;BBRC181,968(1991)
- PresenceandpossIBLeinvolvementofCa/calmodulin-dependentproteinkinasesininsulinreleasefromtheratpancreaticbetacell:I.Niki,etal.;BBRC&191,255(1993)
- InhibitionofacidsecretioningastricparietalcellsbytheCa2+/calmodulin-dependentproteinkinaseIIinhibitorKN-93:N.Mamiya,etal.;BBRC195,608(1993)
- G1cellcyclearrestandapoptosisareinducedinNIH3T3cellsbyKN-93,aninhibitorofCaMK-II(themultifunctionalCa2+/CaMkinase):R.M.Tombes,etal.;CellGrowthDiffer.6,1063(1995)
- CaMKII-independenteffectsofKN93anditsinactiveanalogKN92:reversibleinhibitionofL-typecalciumchannels:L.Gao,etal.;BBRC345,1606(2006)
- KN-93(2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine),acalcium/calmodulin-dependentproteinkinaseIIinhibitor,isadirectextracellularblockerofvoltage-gatedpotassiumchannels:S.Reazadeh,etal.;J.Pharmacol.Exp.Ther.317,292(2006)
- KN-93inhibitsandrogenreceptoractivityandinducescelldeathirrespectiveofp53andAktstatusinprostatecancer:O.W.Rokhlin,etal.;CancerBiol.Ther.9,224(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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