Adipogen/Kirromycin/BVT-0157-M001/1 mg
商品编号：
BVT-0157-M001
品牌：
Adipogen Inc
市场价：
¥3400.00
美元价：
2040.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Mocimycin; Delvomycin; MYC 8003; NSC 316094 |
| Product Type | Chemical |
| Properties | |
| Formula | C43H60N2O12 |
| MW | 796.9 |
| Merck Index | 14: 6225 |
| CAS | 50935-71-2 |
| RTECS | QA2805000 |
| Source/Host Chemicals | Isolated from Streptomyces collinus. |
| Purity Chemicals | ≥96% (HPLC) |
| Appearance | Yellow powder. |
| Solubility | Soluble in methanol or DMSO. |
| Identity | Determined by 1H-NMR and UV. |
| InChi Key | HMSYAPGFKGSXAJ-PAHGNTJYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Antibiotic. Member of the elfermycin group.
- Antibacterial.
- Protein biosynthesis inhibitor.
- Specifically interacts with the bacterial elongation factor EF-Tu and prevents the release of EF-Tu from the bacterial ribosome after GTP hydrolysis. In the absence of ribosomes it induces EF-Tu-dependent hydrolysis of GTP.
- Animal growth promoter used in poultry breeding.
Product References
- Metabolic products of microorganisms. 99. Kirromycin: H. Wolf & H. Zähner; Arch. Mikrobiol. 83, 147 (1972)
- Kirromycin, an inhibitor of the 30 S ribosomal subunits function: H. Wolf, et al.; FEBS Lett. 21, 347 (1972)
- The total structure of the novel antibiotic mocimycin: C. Vos & P.E.J. Verwiel; Tetrahedron Lett. 1973, 5173 (1973)
- Kirromycin, an inhibitor of the protein biosynthesis that acts on elongation factor Tu: H. Wolf, et al.; PNAS 71, 4910 (1974)
- Mechanism of the inhibition of protein synthesis by kirromycin. Role of elongation factor Tu and ribosomes: H. Wolf, et al.; Eur. J. Biochem. 75, 67 (1977)
- Action of pulvomycin and kirromycin on eukaryotic cells: B. Schmid, et al.; FEBS Lett. 96, 189 (1978)
- Energetic aspects of the EF-Tu-dependent GTPase activity. A study using the antibiotic kirromycin: V. Bocchin, et al.; Eur. J. Biochem. 113, 53 (1980)
- Effects of elfamycins on elongation factor Tu from Escherichia coli and Staphylococcus aureus: C.C. Hall, et al.; Antimicrob. Agents Chemother. 33, 322 (1989)
- Inhibitory mechanisms of antibiotics targeting elongation factor Tu: T. Hogg, et al.; Curr. Prot. Pept. Sci. 3, 121 (2002)
- Elongation factor Tu-targeted antibiotics: four different structures, two mechanisms of action: A. Parmeggiani & P. Nissen; FEBS Lett. 580, 4576 (2006) (Review)
- Molecular analysis of the kirromycin biosynthetic gene cluster: T. Weber, et al.; Chem. Biol. 15, 175 (2008)
- GTPase activation of elongation factor EF-Tu by the ribosome during decoding: J.-C. Schuette, et al.; EMBO J. 28, 755 (2009)
- Interaction of apicoplast-encoded elongation factor EF-Tu with nuclear-encoded EF-Ts mediates translation in the Plasmodium falciparum plastid: S. Biswas, et al.; Intern. J. Parasitol. 41, 417 (2011)
- The phosphopantetheinyl transferase kirP activates the ACP and PCP domains of the kirromycin NRPS/ PKS of Streptomyces collinus Tü 365: M. Pavlidou, et al.; FEMS Microbiol. Lett. 319, 26 (2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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