Adipogen/Ki20227/SYN-1049-M050/50 mg
商品编号：
SYN-1049-M050
品牌：
Adipogen Inc
市场价：
¥17820.00
美元价：
10692.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Ki-20227 |
| Product Type | Chemical |
| Properties | |
| Formula | C24H24N4O5S |
| MW | 480.5 |
| CAS | 623142-96-1 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: c-fms | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | SHPFDGWALWEPGS-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Ki20227 is a c-fms tyrosine kinase inhibitor. It has IC(50) values of 2, 12, 451 and 217nM for c-Fms, VEGFR-2, c-Kit and PDGFRβ respectively.
Product References
- A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model: H. Ohno, et al.; Mol. Cancer Ther. 5, 2634 (2006)
- The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model: H. Ohno, et al.; Eur. J. Immunol. 38, 283 (2008)
- M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis: Y. Kubota, et al.; J. Exp. Med. 206, 1089 (2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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