![Adipogen/K777 [K11777]/AG-CR1-0158-M005/5 mg](https://www.ebiomall.cn/images/adipogen/ag-cr1-0158_k777_1.png)
Adipogen/K777 [K11777]/AG-CR1-0158-M005/5 mg
商品编号：
AG-CR1-0158-M005
品牌：
Adipogen Inc
市场价：
¥3200.00
美元价：
1920.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | K-777; K-11777; N-Pip-F-hF-VS Phenyl; N-Pip-phenylalanine-homophenylalanine-vinyl sulfone phenyl; N-Methyl-piperazinyl-L-phenylalanyl-L-homophenylalanyl-vinyl sulfone |
| Product Type | Chemical |
| Properties | |
| Formula | C32H38N4O4S |
| MW | 574.7 |
| CAS | 233277-99-1 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Other Product Data | Contains ~10% other isomer product. |
| InChi Key | RHJLQMVZXQKJKB-FPHSVDBKSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Broad-range cathepsin inhibitor (for all known cathepsins) useful for inflammasome inhibition. Inhibits cathepsins B, L, S, C, V, K and papain in cell-free assays. Inhibits cathepsin X as well.
- Suppresses particle-induced NLRP3 activation and IL-1beta secretion more efficiently than Ca074Me (cathepsin B inhibitor), which in contrast suppresses nigericin-induced IL-1beta secretion.
- Selectively inhibits particle-induced cell death but not nigericin- or sAdT-induced cell death.
- Potent and selective CCR4 antagonist.
- Potent, irreversible cysteine protease inhibitor.
- Potent cysteine protease cruzain (cruzipain) inhibitor. Active against Trypanosoma cruzi the causative agent of Chagas' disease, a parasitic infection which is a leading cause of heart disease.
- Antiparasitic agent with anti-trypanosomal , anti-leishmanial, anti-schistosomiasis, anti-amebiasis (EhCP1 (E. Histolytica cysteine proteinase 1)), anti-anthelmintic (hookworm first-stage larvae) and anti-cryptosporidial activity.
- Shown to have antiviral activity by targeting cathepsin-mediated cell entry.
Product References
- Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection: J. Engel, et al.; J. Exp. Med. 188, 725 (1998)
- In vitro evaluation of the disposition of A novel cysteine protease inhibitor: W. Jacobsen, et al.; Drug Metab. Dispos. 28, 1343 (2000)
- Leishmania tropica: cysteine proteases are essential for growth and pathogenicity: H. Mahmoudzadeh-Niknam, et al.; Exp. Parasitol. 106, 158 (2004)
- A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi: S.C. Barr, et al.; Antimicrob. Agents Chemother. 49, 5160 (2005)
- Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model: S.G. Melendez-Lopez, et al.; Eukaryot. Cell 6, 1130 (2007)
- Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor: M.H. Abdulla, et al.; PLoS Med. 4, e14 (2007)
- Vinyl sulfones as antiparasitic agents and a structural basis for drug design: I.D. Kerr, et al.; J. Biol. Chem. 284, 25697 (2009)
- In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi: Y.T. Chen, et al.; PLoS Negl. Trop. Dis. 4, e825 (2010)
- Cure of hookworm infection with a cysteine protease inhibitor: J.J. Vermeire, et al.; PLoS Negl. Trop. Dis. 6, e1680 (2012)
- Mapping inhibitor binding modes on an active cysteine protease via NMR spectroscopy: G.M. Lee, et al.; Biochem. 51, 10087 (2012)
- Active cathepsins B, L, and S in murine and human pancreatitis: V. Lyo, et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 303, G894 (2012)
- Internalization of CCR4 and inhibition of chemotaxis by K777, a potent and selective CCR4 antagonist: T. Sato, et al.; Pharmacology 91, 305 (2013)
- A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection: M. Ndao, et al.; Antimicrob. Agents Chemother. 57, 6063 (2013)
- Reversible cysteine protease inhibitors show promise for a Chagas Disease cure: M. Ndao, et al.; Antimicrob. Agents Chemother. 58, 1167 (2014)
- Protease inhibitors targeting coronavirus and filovirus entry: Y. Zhou, et al.; Antiviral Res. 116, 76 (2015)
- Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1beta activation: G.M. Orlowski, et al.; J. Leuk. Biol. 101 (Epub ahead of print) (2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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