![脂肪原/K777[K11777]/AG-CR1-0158-M001/1毫克](https://www.ebiomall.cn/images/adipogen/ag-cr1-0158_k777_1.png)
脂肪原/K777[K11777]/AG-CR1-0158-M001/1毫克
商品编号：
AG-CR1-0158-M001
品牌：
Adipogen Inc
市场价：
¥800.00
美元价：
480.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | K-777;K-11777;N-Pip-F-hF-VSPhenyl;N-Pip-phenylalanine-homophenylalanine-vinylsulfonephenyl;N-Methyl-piperazinyl-L-phenylalanyl-L-homophenylalanyl-vinylsulfone |
| ProductType | Chemical |
| Properties | |
| Formula | C32H38N4O4S |
| MW | 574.7 |
| CAS | 233277-99-1 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Solid. |
| Solubility | SolubleinDMSO.Insolubleinwater. |
| Identity | Determinedby1H-NMR. |
| OtherProductData | Contains~10%otherisomerproduct. |
| InChiKey | RHJLQMVZXQKJKB-FPHSVDBKSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Broad-rangecathepsininhibitor(forallknowncathepsins)usefulforinflammasomeinhibition.InhibitscathepsinsB,L,S,C,V,Kandpapainincell-freeassays.InhibitscathepsinXaswell.
- Suppressesparticle-inducedNLRP3activationandIL-1betasecretionmoreefficientlythanCa074Me(cathepsinBinhibitor),whichincontrastsuppressesnigericin-inducedIL-1betasecretion.
- Selectivelyinhibitsparticle-inducedcelldeathbutnotnigericin-orsAdT-inducedcelldeath.
- PotentandselectiveCCR4antagoNIST.
- Potent,irreversIBLecysteineproteaseinhibitor.
- Potentcysteineproteasecruzain(cruzipain)inhibitor.ActiveagainstTrypanosomacruzithecausativeagentofChagas"disease,aparasiticinfectionwhichisaleADIngcauseofheartdisease.
- Antiparasiticagentwithanti-trypanosomal,anti-leishmanial,anti-schistosomiasis,anti-amebiasis(EhCP1(E.Histolyticacysteineproteinase1)),anti-anthelmintic(hookwormfirst-stagelarvae)andanti-cryptosporidialactivity.
- Showntohaveantiviralactivitybytargetingcathepsin-mediatedcellentry.
ProductReferences
- CysteineproteaseinhibitorscureanexperimentalTrypanosomacruziinfection:J.Engel,etal.;J.Exp.Med.188,725(1998)
- InvitroevaluationofthedispositionofAnovelcysteineproteaseinhibitor:W.Jacobsen,etal.;DrugMetab.Dispos.28,1343(2000)
- Leishmaniatropica:cysteineproteasesareessentialforgrowthandpathogenicity:H.Mahmoudzadeh-Niknam,etal.;Exp.Parasitol.106,158(2004)
- AcysteineproteaseinhibitorprotectsdogsfromcardiacdamageduringinfectionbyTrypanosomacruzi:S.C.Barr,etal.;Antimicrob.AgentsChemother.49,5160(2005)
- UseofrecombinantEntamoebahistolyticacysteineproteinase1toidentifyapotentinhibitorofamebicinvasioninahumancolonicmodel:S.G.Melendez-Lopez,etal.;Eukaryot.Cell6,1130(2007)
- Schistosomiasismansoni:novelchemotherapyusingacysteineproteaseinhibitor:M.H.ABDulla,etal.;PLoSMed.4,e14(2007)
- Vinylsulfonesasantiparasiticagentsandastructuralbasisfordrugdesign:I.D.Kerr,etal.;J.Biol.Chem.284,25697(2009)
- InvitroandinvivostudiesofthetrypanocidalpropertiesofWRR-483againstTrypanosomacruzi:Y.T.Chen,etal.;PLoSNegl.Trop.Dis.4,e825(2010)
- Cureofhookworminfectionwithacysteineproteaseinhibitor:J.J.Vermeire,etal.;PLoSNegl.Trop.Dis.6,e1680(2012)
- MappinginhibitorbindingmodesonanactivecysteineproteaseviaNMRspectroscopy:G.M.Lee,etal.;Biochem.51,10087(2012)
- ActivecathepsinsB,L,andSinmurineandhumanpancreatitis:V.Lyo,etal.;Am.J.Physiol.Gastrointest.LiverPhysiol.303,G894(2012)
- InternalizationofCCR4andinhibitionofchemotaxisbyK777,apotentandselectiveCCR4antagonist:T.Sato,etal.;Pharmacology91,305(2013)
- AcysteineproteaseinhibitorrescuesmicefromalethalCryptosporidiumparvuminfection:M.Ndao,etal.;Antimicrob.AgentsChemother.57,6063(2013)
- ReversiblecysteineproteaseinhibitorsshowpromiseforaChagasDiseasecure:M.Ndao,etal.;Antimicrob.AgentsChemother.58,1167(2014)
- Proteaseinhibitorstargetingcoronavirusandfilovirusentry:Y.Zhou,etal.;AntiviralRes.116,76(2015)
- Multiplecathepsinspromoteinflammasome-independent,particle-inducedcelldeathduringNLRP3-dependentIL-1betaactivation:G.M.Orlowski,etal.;J.Leuk.Biol.101(Epubaheadofprint)(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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