Adipogen/K-252c/AG-CN2-0097-M001/1 mg
商品编号：
AG-CN2-0097-M001
品牌：
Adipogen Inc
市场价：
¥1400.00
美元价：
840.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Staurosporineaglycone;Staurosporinone;AntibioticK252c;6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one |
| ProductType | Chemical |
| Properties | |
| Formula | C20H13N3O |
| MW | 311.4 |
| CAS | 85753-43-1 |
| Source/HostChemicals | IsolatedfromStreptomyceslongisporoflavus. |
| PurityChemicals | ≥97%(HPLC) |
| Appearance | Off-whitetoyellowcrystallinesolid. |
| Solubility | SolubleinDMSOormethanol.Insolubleinwater. |
| InChiKey | MEXUTNIFSHFQRG-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. Stocksolutionsarestableforatleast3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Indolocarbazolealkaloidantibiotic.[1].
- PotentcellpermeablereversIBLeandATP-competitivePKC(proteinkinaseC)inhibitorwith10-foldselectivityoverPKA(proteinkinaseA)[1-5].
- Anticancercompound.Cytotoxicagaintvariouscancercelllines[6,9,11].
- Apoptosisinducer[11].
- AntiviralcompoundagainstGCV-sensitiveand-resistantstrainsofhumancytomegalovirus(HCMV)[7].
- LACTB(β-lactamase),malatedehydrogenase(MDH2,MDHC,MDH1B,ME1.ME2,ME3)andchymotrypsininhibitor[8].
- Inhibitsmixedlineagekinase(MLK)[10].
ProductReferences
- K-252b,candd,potentinhibitorsofproteinkinaseCfrommicrobialorigin:S.Nakanishi,etal.;J.Antibiot.39,1066(1986)
- ThestructuresofthenovelproteinkinaseCinhibitorsK-252a,b,candd:T.Yasuzawa,etal.;J.Antibiot.39,1072(1986)
- Staurosporine,K-252andUCN-01:potentbutnonspecificinhibitorsofproteinkinases:U.T.Ruegg&G.M.Burgess;TIPS10,218(1989)
- ProteinkinaseCinhibitors;structure-activityrelationshipsinK252c-relatedcompounds:S.Fabre,etal.;Bioorg.Med.Chem.1,193(1993)
- Non-glycosidic/non-aminoalkyl-substitutedindolocarbazolesasinhibitorsofproteinkinaseC:J.Kleinschroth,etal.;Bioorg.Med.Chem.Lett.3,1959(1993)
- Staurosporineaglycone(K252-c)andarcyriaflavinAfromthemarineascidian,Eudistomasp:P.A.Horton,etal.;Experientia50,843(1994)
- IndolocarbazolesexhibitstrongantiviralactivityagainsthumancytomegalovirusandarepotentinhibitorsofthepUL97proteinkinase:A.Zimmermann,etal.;AntiviralRes.48,49(2000)
- Kinaseinhibitors:notjustforkinasesanymore:S.L.McGovern&B.K.Shoichet;J.Med.Chem.46,1478(2003)
- BIOLOGicaltargetsofantitumorindolocarbazolesbearingasugarmoiety:M.Prudhomme;Curr.Med.Chem.AnticancerAgents4,509(2004)
- Synthesisandmixedlineagekinaseactivityofpyrrolocarbazoleandisoindoloneanalogsof(+)K-252a:R.L.Hudkins,etal.;J.Med.Chem.50,433(2007)
- Twoindolocarbazolealkaloidswithapoptosisactivityfromamarine-derivedactinomyceteZ(2)039-2:R.Liu,etal.;Arch.Pharm.Res.30,270(2007)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
