Adipogen/K-252a/AG-CN2-0019-M001/1 mg
商品编号：
AG-CN2-0019-M001
品牌：
Adipogen Inc
市场价：
¥3200.00
美元价：
1920.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | SF2370;AntibioticK252a;AntibioticSF2370 |
| ProductType | Chemical |
| Properties | |
| Formula | C27H21N3O5 |
| MW | 467.5 |
| CAS | 99533-80-9 |
| RTECS | NZ0550000 |
| Source/HostChemicals | IsolatedfromNonomuraealongicatenachiba. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitepowder. |
| Solubility | SolubleinDMSO,methanol,methylenechloride,ethylacetateoracetone.Insolubleinwater. |
| InChiKey | KOZFSFOOLUUIGY-SOLYNIJKSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic[1].
- PKC,PKAandPKGinhibitor[1,2,4].
- Showsneurotropicactivitybyinducingneuriteoutgrowth[3,8,11,16].
- HighlypotentcellpermeableCaMkinase[6]andphosphorylaseinhibitor[5].
- TyrosineproteinkinaseinhibitoroftheTRKfamily[7].
- Antiproliferative[9,10,13,15].
- Apoptosisinducer[12,16].
- Cellcyclearrestinducer[12].
- Potentialdrugforpsoriasistreatment[14].
ProductReferences
- K-252a,apotentinhibitorofproteinkinaseCfrommicrobialorigin:H.Kase,etal.;J.Antibiot.(Tokyo)39,1059(1986)
- K-252compounds,novelandpotentinhibitorsofproteinkinaseCandcyclicnucleotide-dependentproteinkinases:H.Kase,etal.;BBRC142,436(1987)
- K-252a:aspecificinhibitoroftheactionofnervegrowthfactoronPC12cells:s.Koizumi,etal.;J.Neurosci.8,715(1988)
- Staurosporine,K-252andUCN-01:potentbutnonspecificinhibitorsofproteinkinases:U.T.Ruegg&G.M.Burgess;TIPS10,218(1989)(Review)
- K252aisapotentandselectiveinhibitorofphosphorylasekinase:L.H.Elliott,etal.;BBRC171,148(1990)
- PotentandpreferentialinhibitionofCa2+/calmodulin-dependentproteinkinaseIIbyK252aanditsderivative,KT5926:Y.Hashimoto,etal.;BBRC181,423(1991)
- K252aisaselectiveinhibitorofthetyrosineproteinkinaseactivityofthetrkfamilyofoncogenesandneurotrophinreceptors:P.Tapley,etal.;Oncogene7,371(1992)
- SpecificinhibitionofNGFreceptortyrosinekinaseactivitybyK-252a:K.Muroya,etal.;Biochim.Biophys.Acta1135,353(1992)
- K252a:anewblockerofthecell-cycleatG1phaseinahumanhepatomacellline:T.Nakayama,etal.;Experientia49,876(1993)
- Anti-proliferativeeffectofthekinaseinhibitorK252aonhumanprostaticcarcinomacelllines:R.Delsite&D.Djakiew;J.Androl.17,481(1996)
- K252aandstaurosporinemicrobialalkaloidtoxinsasprototypeofneurotropicdrugs:P.Lazarovici,etal.;Adv.Exp.Med.Biol.391,367(1996)(Review)
- K252ainducescellcyclearrestandapoptosisbyinhibitingCdc2andCdc25c:L.S.Chin,etal.;CancerInvest.17,391(1999)
- K252ainhibitstheoncogenicpropertiesofMet,theHGFreceptor:A.Morotti,etal.;Oncogene21,4885(2002)
- K252a,ahigh-affinitynervegrowthfactorreceptorblocker,improvespsoriasis:aninvivostudyusingtheseverecombinedimmunodeficientmouse-humanskinmodel:S.P.Raychaudhuri,etal.;J.Invest.Dermatol.122,812(2004)
- K252ainhibitsproliferationofovariancancercellsbyupregulatingp21WAF1:N.Takai,etal.;Oncol.Rep.14,141(2005)
- K252asuppressesneuronalcellsapoptosisthroughinhibitingthetranslocationofBaxtomitochondriainducedbytheMLK3/JNKsignalingaftertransientglobalbrainischemiainrathippocampalCA1subregion:Q.Wang,etal.;J.Recept.Signal.Transduct.Res.31,307(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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