Adipogen/IWR-1-endo/AG-CR1-3581-M005/5 mg
商品编号：
AG-CR1-3581-M005
品牌：
Adipogen Inc
市场价：
¥1600.00
美元价：
960.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide |
| ProductType | Chemical |
| Properties | |
| Formula | C25H19N3O3 |
| MW | 409.4 |
| CAS | 1127442-82-3 |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSOorDMF. |
| OtherProductData | Note:Sparinglysolubleinaqueousbuffers.Formaximumsolubilityinaqueousbuffers,dissolvefirstinDMSOandthendilutewiththeaqueousbufferofchoice.Solubilityina1:3solutionofDMSO:PBS(pH7.2)(~0.25mg/ml).Itisrecommendedtousefreshaqueoussolutionsandnottostorethemformorethanoneday. |
| InChiKey | ZGSXEXBYLJIOGF-UBYGHTOYDO |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentandreversIBLecellpermeableWntpathwaysignalinginhibitor[1,2,4,5].
- InhibitsWnt-inducedaccumulationofβ-catenin,leADIngtoproteasomaldegradationofthisproteinthroughadestructioncomplexwhichconsistsofApc,Axin2,CK1andGSK-3β.Stabilizesthedestructioncomplex,increasingthelevelofAxin2proteinwithoutchangingthelevelsofApcorGSK-3β.
- Tankyrase-1(TNKS1/PARP5a)andTankyrase-2(TNKS2/PARP5b)inhibitor(invitroauto-PARsylationassay)[3,6].
ProductReferences
- Smallmolecule-mediateddisruptionofWnt-dependentsignalingintissueregenerationandcancer:B.Chen,etal.;Nat.Chem.Biol.5,100(2009)
- Structure-activityrelationshipstudiesofsmall-moleculeinhibitorsofWntresponse:J.Lu,etal.;Bioorg.Med.Chem.Lett.19,3825(2009)
- TankyraseinhibitionstabilizesaxinandantagonizesWntsignalling:S.M.Huang,etal.;Nature461,614(2009)
- Wntsignalingisrequiredforearlydevelopmentofzebrafishswimbladder:A.Yin,etal.;PLoSOne6,e18431(2011)
- PerturbationofzebrafishswimbladderdevelopmentbyenhancingWntsignalinginWif1morphants:A.Yin,etal.;Biochim.Biophys.Acta1823,236(2012)
- Structuralbasisofselectiveinhibitionofhumantankyrases:M.Narwal,etal.;J.Med.Chem.55,1360(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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