Adipogen/Itaconic acid/AG-CN2-0426-G001/1 g
商品编号：
AG-CN2-0426-G001
品牌：
Adipogen Inc
市场价：
¥400.00
美元价：
240.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Methylenesuccinicacid;2-Propene-1,2-dicarboxylicacid;Itaconate |
| ProductType | Chemical |
| Properties | |
| Formula | C5H6O4 |
| MW | 130.1 |
| CAS | 97-65-4 |
| PurityChemicals | ≥99% |
| Appearance | Whitepowder. |
| Solubility | Solubleinwater,ethanolormethanol. |
| InChiKey | GDMMRLCQKPSXQG-USNJAYOWSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Mammalianantibacterialmetabolite.
- Inhibitorofisocitratelyase,thekeyenzymeoftheglyoxylatecycle,essentialforbacterialgrowth[1,4].
- Antimicrobial.Antibacterial[1,3,4].
- Inhibitsthegrowthofbacteriaexpressingisocitratelyase[1,3,4].
- Phosphofructokinase(PFKII)inhibitor.Suppressesglycolysisbydecreasingtheleveloffructose2,6-bisphosphate,resultingindecreasedvisceralfat[2].
- Mightbeinvolvedintheregulationofmetabolism[2].
- Oneofthemosthighlyinducedmetabolitesinactivatedmacrophages.
- Exertsanti-inflammatoryeffectsinvitroandinvivo.
- Regulatessuccinatelevelsbyinhibitingsuccinatedehydrogenase(SDH).
- Regulatesmitochondrialrespirationandcytokineproduction.
- MightinduceinflammasomeactivationandconsequentlyIL-1βsecretionbygeneratingROS.
ProductReferences
- Itaconate,anisocitratelyase-directedinhibitorinPseudomonasindigofera:B.A.McFadden&S.Purohit;J.Bacteriol.131,136(1977)
- Itaconatereducesvisceralfatbyinhibitingfructose2,6-bisphosphatesynthesisinratliver:A.Sakai,etal.;Nutrition20,997(2004)
- Itaconicacidisamammalianmetaboliteinducedduringmacrophageactivation:C.L.Strelko,etal.;JACS133,16386(2011)
- Immune-responsivegene1proteinlinksmetabolismtoimmunitybycatalyzingitaconicacidproduction:A.Michelucci,etal.;PNAS110,7820(2013)
- Itaconatelinksinhibitionofsuccinatedehydrogenasewithmacrophagemetabolicremodelingandregulationofinflammation:V.Lampropoulou,etal.;CellMetab.24,158(2016)
- Foodfight:Roleofitaconateandothermetabolitesinantimicrobialdefense:H.H.Luan&R.Medzhitov;CellMetab.24,379(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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