Adipogen/Isoliquiritigenin/AG-CN2-0459-M010/10 mg
商品编号：
AG-CN2-0459-M010
品牌：
Adipogen Inc
市场价：
¥2400.00
美元价：
1440.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ISL;GU17;4,2",4"-Trihydroxychalcone |
| ProductType | Chemical |
| Properties | |
| Formula | C15H12O4 |
| MW | 256.3 |
| CAS | 961-29-5 |
| Source/HostChemicals | Synthetic.OriginallyisolatedfromGlycyrrizasp. |
| PurityChemicals | ≥97%(HPLC) |
| Appearance | Yellowsolid. |
| Solubility | SolubleinDMSO,methanolorethanol. |
| InChiKey | DXDRHHKMWQZJHT-FPYGCLRLSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Anticancer.Apoptosisinducerandcellproliferationinhibitor.Autophagyinducer.
- Anti-angiogenic.VEGF/VEGFR-2signalinginhibitor.
- Antioxidantandantibacterial.
- AMPK-mediatedGSK3βinhibitor.
- Anti-inflammatory.InhibitstranslocationandactivationofNF-κBbyblockingphosphorylationandsubsequentdegradationofIκBα.
- DownregulatesTRIF-dependentsignalingpathwaysofTLRsbyinhibitingTBK1kinaseactivity.BlocksLPS-inducedTLR4/MD2complexsignaling.
- NLRP3inflammasomeactivationinhibitor.InhibitsNLRP3-activatedASColigomerization.
- CanblocktheNLRP3inflammasomeatboththeprimingstepandtheactivationstep.
- H(2)histaminereceptorsignalinginhibitor.
- Anti-diabetic.Antihyperglycemic.
- Aldosereductaseinhibitor.
- Vasorelaxant.Solubleguanylylcyclaseactivator.
- GABAAreceptorpositiveallostericmodulator.
- Potentcysticfibrosistransmembraneconductanceregulator(CFTR)inhibitor.
- ShowntoinhibitbreastcancerstemcellsthroughWIF1demethylation.
- ShowsoutstandingmatrixpropertiesforMALDI-TOF-MSanalysisofoligosaccharides.
ProductReferences
- Thepotentanti-tumor-promotingagentisoliquiritigenin:S.Yamamoto,etal.;Carcinogenesis12,317(1991)
- Anti-plateletactionofisoliquiritigenin,analdosereductaseinhibitorinLicorice:M.Tawata,etal.;Eur.J.Pharmacol.212,87(1992)
- Vasorelaxanteffectofisoliquiritigenin,anovelsolubleguanylatecyclaseactivator,inrataorta:S.M.Yu&S.C.Kuo;Br.J.Pharmacol.114,1587(1995)
- Antioxidantconstituentsfromlicoriceroots:isolation,structureelucidationandantioxidativecapacitytowardLDLoxidation:J.Vaja,etal.;FreeRADIc.Biol.Med.23,302(1997)
- Isoliquiritigenininhibitscellproliferationandinducesapoptosisinhumanhepatomacells:Y.L.Hsu,etal.;PlantaMed.71,130(2005)
- Isoliquiritigenininducesapoptosisandcellcyclearrestthroughp53-dependentpathwayinHepG2cells:Y.L.Hsu,etal.;LifeSci.77,279(2005)
- IsoliquiritigeninselectivelyinhibitsH(2)histaminereceptorsignalling:D.C.Kim,etal.;Mol.Pharmacol.70,493(2006)
- IsoliquiritigenininhibitsIkappaBkinaseactivityandROSgenerationtoblockTNF-alphainducedexpressionofcelladhesionmoleculesonhumanendothelialcells:S.Kumar,etal.;Biochem.Pharmacol.73,1602(2007)
- AMPK-mediatedGSK3betainhibitionbyisoliquiritigenincontributestoprotectingmitochondriaagainstiron-catalyzedoxidativestress:S.H.Choi,etal.;Biochem.Pharmacol.79,1352(2010)
- IsoliquiritigeninsuppressestheToll-interleukin-1receptordomain-containingadapterinducinginterferon-beta(TRIF)-dependentsignalingpathwayofToll-likereceptorsbytargetingTBK1:S.J.Park&H.S.Youn;J.Agric.FoodChem.58,4701(2010)
- Isoliquiritigenin,achalconecompound,isapositiveallostericmodulatorofGABAAreceptorsandshowshypnoticeffects:S.Cho,etal.;BBRC413,637(2011)
- Isoliquiritigenin(4,2",4"-trihydroxychalcone):anewmatrix-assistedlaserdesorption/ionizationmatrixwithoutstandingpropertiesfortheanalysisofneutraloligosaccharides:H.Yang,etal.;Anal.Chim.Acta70,45(2011)
- Novelactionofthechalconeisoliquiritigeninasacysticfibrosistransmembraneconductanceregulator(CFTR)inhibitor:potentialtherapyforcholeraandpolycystickidneydisease:C.Muanprasat,etal.;J.Pharmacol.Sci.118,82(2012)
- DietarycompoundisoliquiritigenininhibitsbreastcancerneoangiogenesisviaVEGF/VEGFR-2signalingpathway:Z.Wang,etal.;PLoSOne8,e68566(2013)
- Invivoanti-diabeticactivityofderivativesofisoliquiritigeninandliquiritigenin:T.Gaur,etal.;Phytomedicine21,415(2014)
- MicroRNA-25regulateschemoresistance-associatedautophagyinbreastcancercells,aprocessmodulatedbythenaturalautophagyinducerisoliquiritigenin:Z.Wang,etal.;Oncotarget5,7013(2014)
- IsoliquiritigeninisapotentinhibitorofNLRP3inflammasomeactivationanddiet-inducedadiposetissueinflammation:H.Honda,etal.;J.Leukoc.Biol.96,1087(2014)
- DietarycompoundisoliquiritigeninpreventsmammarycarcinogenesisbyinhibitingbreastcancerstemcellsthroughWIF1demethylation:N.Wang,etal.;Oncotarget6,9854(2015)
- AReview:ThePharmacologyofIsoliquiritigenin:F.Peng,etal.;Phytother.Res.29,969(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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