脂肪原/离子霉素（游离酸）/AG-CN2-0416-M005/5 mg
商品编号：
AG-CN2-0416-M005
品牌：
Adipogen Inc
市场价：
¥4800.00
美元价：
2880.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AntibioticSQ23377;EM94 |
| ProductType | Chemical |
| Properties | |
| Formula | C41H72O9 |
| MW | 709.0 |
| CAS | 56092-81-0 |
| RTECS | NO0600000 |
| Source/HostChemicals | IsolatedfromStreptomycesconglobatus. |
| PurityChemicals | ≥98%(HPLC,TLC) |
| Appearance | Waxyyellowtocolorlesssolid. |
| Solubility | SolubleinmethanolorDMSO. |
| InChiKey | PGHMRUGBZOYCAA-ZRDXXTDTSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Keepunderinertgas. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic[1].
- PotentandhighlyselectiveCa2+ionophore.CommonlyusedtomodifyintracellularcalciumlevelstostudycalciumtransportacrossBIOLOGicalmembranesandtocalibratefluorescentCa2+indicators[2,3].
- IonomycinalsotransportsPb2+andsomeotherdivalentcations,aswellasseverallanthanideseriestrivalentcationsatefficienciesthataregreaterthanorequaltothoseforCa2+[3,9].
- Apoptosisinducer[4,7].InducesapoptoticneuronaldegenerationinembryoniccorticalneuronsandcellcyclearrestatG1phaseandinducescentraldemyelination[6].
- Usedtostimulatetheintracellularproductionofthecytokines,interferon,perforin,IL-2andIL-4usuallyinconjunctionwithPMA[5,8].
- ADAM10agoNIST[10].
- PotentinducerofsheddingCXCL16[10].
- TREK-1channelsinhibitor[11].
- PPARγligandwithauniquebindingmode.Showseffectiveglucose-loweringactivityinamousemodelofdiabetes[12].
ProductReferences
- Ionomycin,anewpolyetherantibiotic:W.C.Liu,etal.;J.Antibiot.31,815(1978)
- Characterizationofionomycinasacalciumionophore:C.Liu&T.E.Hermann;J.Biol.Chem.253,5892(1978)
- Cationtransportandspecificityofionomycin.ComparisonwithionophoreA23187inratlivermitochondria:R.F.Kauffman,etal.;J.Biol.Chem.255,2735(1980)
- Ionophore-inducedapoptosis:roleofDNAfragmentationandcalciumfluxes:D.M.Ojcius,etal.;Exp.CellRes.197,43(1991)
- Contrastingeffectoftransforminggrowthfactortypebeta1(TGF-beta1)onproliferationandinterleukin-2receptorexpressioninactivatedandrapidlycyclingimmature(CD3-CD4-CD8-)thymocytes:A.Dupuyd"Angeac,etal.;J.Cell.Physiol.154,44(1993)
- Ca2+ionophore-inducedapoptosisonculturedembryonicratcorticalneurons:N.Takei&Y.Endo;BrainRes.652,65(1994)
- Differentialactivationofacalcium-dependentendonucleaseinhumanBlymphocytes.Roleinionomycin-inducedapoptosis:K.M.Aagaard-Tillery,etal.;J.Immunol.155,3297(1995)
- FlowcytometricanalysisofintracellularIFN-γ,IL-4andIL-10inCD3+4+T-cellsfromratspleen:E.M.Caraher,etal.;J.Immunol.Methods244,29(2000)
- TheionophorenigericintransportsPb2+withhighactivityandselectivity:acomparisontomonensinandionomycin:S.A.Hamidinia,etal.;Biochemistry43,15956(2004)
- ConstitutiveexpressionandregulatedreleaseofthetransmembranechemokineCXCL16inhumanandmurineskin:F.Scholz,etal.;J.Invest.Dermatol.127,1444(2007)
- Calcium-dependentinhibitionofadrenalTREK-1channelsbyangiotensinIIandionomycin:J.J.Enyeart,etal.;Am.J.Physiol.CellPhysiol.301,C619(2011)
- Identificationoftheantibioticionomycinasanunexpectedperoxisomeproliferator-activatedreceptorγ(PPARγ)ligandwithauniquebindingmodeandeffectiveglucose-loweringactivityinamousemodelofdiabetes:W.Zheng,etal.;Diabetologia56,401(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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