Adipogen/Ingenol-3-angelate/AG-CN2-0012-M005/5 mg
商品编号：
AG-CN2-0012-M005
品牌：
Adipogen Inc
市场价：
¥8400.00
美元价：
5040.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PEP005;I3A;Ingenolmebutate |
| ProductType | Chemical |
| Properties | |
| Formula | C25H34O6 |
| MW | 430.5 |
| CAS | 75567-37-2 |
| Source/HostChemicals | Semi-synthetic. |
| PurityChemicals | ≥97%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solublein100%ethanol,DMSOordichloromethane. |
| Identity | Determinedby1H-NMR. |
| OtherProductData | ThestartingmaterialingenolwasisolatedfromEuphorbialatyris. |
| InChiKey | VDJHFHXMUKFKET-XCHJBCONSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- SpecificproteinkinaseC(PKC)activator[1].
- SelectiveactivatorofPKCisoforms,likePKCθinTcells[1,5,8].
- Antiproliferativeandproapoptotic(necrotic)[2,3,5].
- Immunostimulant[6].
- Chemotherapeutic[4,6].
- Anticancercompound[2,3,5].
- Efficaciousagentagainstactinickerastosis[7].
- Antileukemic[8].
ProductReferences
- Characterizationoftheinteractionofingenol3-angelatewithproteinkinaseC:N.Kedei,etal.;CancerRes.64,3243(2004)
- Ingenol3-angelateinducesdualmodesofcelldeathanddifferentiallyregulatestumornecrosisfactor-relatedapoptosis-inducingligand-inducedapoptosisinmelanomacells:S.K.Gillespie,etal.;Mol.CancerTher.3,1651(2004)
- PEP005,aselectivesmall-moleculeactivatorofproteinkinaseC,haspotentantileukemicactivitymediatedviathedeltaisoformofPKC:P.Hampson,etal.;Blood106,1362(2005)
- Neutrophilsareakeycomponentoftheantitumorefficacyoftopicalchemotherapywithingenol-3-angelate:J.M.Challacombe,etal.;J.Immunol.177,8123(2006)
- Theanti-tumoragent,ingenol-3-angelate(PEP005),promotestherecruitmentofcytotoxicneutrophilsbyactivationofvascularendothelialcellsinaPKC-deltadependentmanner:P.Hampson,etal.;CancerImmunol.Immunother.57,1241(2008)
- Immunostimulatorycancerchemotherapyusinglocalingenol-3-angelateandsynergywithimmunotherapies:T.T.Le,etal.;Vaccine27,3053(2009)
- Randomized,double-blind,double-dummy,vehicle-controlledstudyofingenolmebutategel0.025%and0.05%foractinickeratosis:L.Anderson,etal.;J.Am.Acad.Dermatol.60,934(2009)
- Novelantileukemiccompoundingenol3-angelateinhibitsTcellapoptosisbyactivatingproteinkinaseCtheta:W.Y.Lee,etal.;JBC285,23889(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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