Adipogen/Indole-3-carbinol/AG-CR1-3637-M500/500 mg
商品编号：
AG-CR1-3637-M500
品牌：
Adipogen Inc
市场价：
¥500.00
美元价：
300.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | I3C;3-Indolemethanol;3-(Hydroxymethyl)indole;BRN0121323;NSC525801;Indinol;3-Indolylcarbinol |
| ProductType | Chemical |
| Properties | |
| Formula | C9H9NO |
| MW | 147.2 |
| CAS | 700-06-1 |
| RTECS | NL9483000 |
| PurityChemicals | ≥96%(HPLC) |
| Appearance | Off-whitesolid. |
| Solubility | SolubleinDMSO,ethanolormethanol.Slightlysolubleinwater(warm). |
| InChiKey | IVYPNXXAYMYVSP-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +20°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Protectfrommoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Naturalbreakdownproductofglucosinolatesfoundincruciferousvegetables.
- Widelyusedmultifunctionalarylhydrocarbonreceptor(AhR)agoNIST.AhRisemergingasatranscriptionfactorinvolvedintheregulationofbothinnateandadaptiveimmuneresponsesinvariousimmunecelltypes,includinglymphocytesandantigen-presentingcells(APCs). StudieshaveassociatedoverexpressionofAHRwiththeactivationofcancerprocessessuchasproliferation,epithelial-to-mesenchymaltransition(EMT),DNAdamage,inflammation,migrationandangiogenesis.
- Usedtoincreasethepopulationofinnatelymphoidcells3(ILC3)ingutmicrobiota.
- Chemopreventiveagentthathasmultipleanticarcinogenicandantitumorpropertiesandsuppressestheproliferationofselectivecancercells,includingbreastcancer,prostatecancer,endometrialcancer,coloncancerandleukemiccells.Protectsagainstnephrotoxicity.
- Proapoptotic.InducescellcyclearrestatG1anddownregulatescellcycle-relatedproteins(CDK4,CDK6,cyclinD1andpRb).Inhibitstelomeraseactivity.
- SIRT1activator.AntiobesityagentthroughinhibitionofADIpogenesisinadipocytes.
- Showntohaveantioxidant,anti-inflammatoryandanti-atherogeniceffects.
ProductReferences
- Indole-3-carbinolinhibitstheexpressionofcyclin-dependentkinase-6andinducesaG1cellcyclearrestofhumanbreastcancercellsindependentofestrogenreceptorsignalling:C.M.Cover,etal.;J.Biol.Chem.273,3838(1998)
- Indole-3-carbinolsuppressestumor-inducedangiogenesisbyinhibitingtubeformationandinducingapoptosis:K.Kunimasa,etal.;Biosci.Biotechnol.Biochem.72,2243(2008)
- Antiplateletandantithromboticactivityofindole-3-carbinolinvitroandinvivo:M.K.Park,etal.;Phytother.Res.22,58(2008)
- Review.Indole-3-carbinolasachemoprotectiveagentinbreastandprostatecancer:H.L.Bradlow;InVivo22,441(2008)
- Indole-3-carbinolimprovessurvivalinlupus-pronemicebyinducingtandemB-andT-celldifferentiationblockades:X.J.Yan,etal.;Clin.Immunol.131,481(2009)
- Antiobesityactivitiesofindole-3-carbinolinhigh-fat-diet-inducedobesemice:H.P.Chang,etal.;Nutrition27,463(2011)
- Indole-3-carbinolinhibitstelomeraseactivityandgeneexpressioninprostatecancercelllines:S.Adler,etal.;AnticancerRes.31,3733(2011)
- Indole-3-carbinoldirectlytargetsSIRT1toinhibitadipocytedifferentiation:Y.Choi,etal.;Int.J.Obes.(Lond)37,881(2013)
- Indole-3-carbinolinhibitsLPS-inducedinflammatoryresponsebyblockingTRIF-dependentsignalingpathwayinmacrophages:J.Jiang,etal.;FoodChem.Toxicol.57,256(2013)
- Indole-3-carbinol,avegetablephytochemical,inhibitsadipogenesisbyregulatingcellcycleandAMPKαsignalling:H.S.Choi,etal.;Biochimie104,127(2014)
- Indole-3-carbinol(I3C)increasesapoptosis,repressesgrowthofcancercells,andenhancesadenovirus-mediatedoncolysis:L.Chen,etal.;CancerBiol.Ther.15,1256(2014)
- Indole-3-carbinolsuppressesNF-κBactivityandstimulatesthep53pathwayinpre-Bacutelymphoblasticleukemiacells:M.Safa,etal.;TumourBiol.36,3919(2015)
- Indole-3-Carbinol(I3C)anditsMajorDerivatives:TheirPharmacokineticsandImportantRolesinHepaticProtection:S.Q.Wang,etal.;Curr.DrugMetab.17,401(2016)
- Researchoncruciferousvegetables,indole-3-carbinol,andcancerprevention:AtributetoLeeW.Wattenberg:N.Fujioka,etal.;Mol.Nutr.FoodRes.60,1228(2016)
- InhibitionofoncogenicBRAFactivitybyindole-3-carbinoldisruptsmicrophthalmia-associatedtranscriptionfactorexpressionandarrestsmelanomacellproliferation:A.Kundu,etal.;Mol.Carcinog.(Epubaheadofprint)(2016)
- Intestinalinflammationandthediet:Isfoodfriendorfoe?B.W.Megna,etal.;WorldJ.Gastrointest.Surg.8,115(2016)
- Indole-3-carbinolprotectsagainstcisplatin-inducedacutenephrotoxicity:roleofcalcitoningene-relatedpeptideandinsulin-likegrowthfactor-1:R.N.El-Naga&Y.F.Mahran;Sci.Rep.6,29857(2016)
- Indole-3-carbinolinducestumorcelldeath:functionfollowsform:B.W.Megna,etal.;J.Surg.Res.204,47(2016)
- Thematernalmicrobiotadrivesearlypostnatalinnateimmunedevelopment:M.GomezdeAguero,etal.;Science351,1296(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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