Adipogen/Imiquimod/AG-CR1-3569-M250/250 mg
商品编号：
AG-CR1-3569-M250
品牌：
Adipogen Inc
市场价：
¥1700.00
美元价：
1020.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline;S26308;R-837 |
| ProductType | Chemical |
| Properties | |
| Formula | C14H16N4 |
| MW | 240.3 |
| CAS | 99011-02-6 |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitepowder. |
| Solubility | SolubleinDMSOordimethylformamide.Insolubleinethanol.Slightlysolubleinwater. |
| Identity | DeterminedbyIR. |
| InChiKey | DOUYETYNHWVLEO-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Stocksolutionsarestableforatleast3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Immuneresponsemodulator[1,2].
- Anti-inflammatory[3,5].
- TLR7agoNIST[3,5].
- Stimulatesproinflammatorycytokineproductioninterferon-α(IFN-α),interleukin-6(IL-6)andtumornecrosisfactor-α(TNF-α)andactivatesNF-κB[3,5].
- Caspase-3activatorthatdirectlyinducesprocaspase-3cleavage[4].
- Anti-cancercompound[4,9].
- Apoptosisinducer[4,9].
- Antiproliferative,independentofimmunesystemactivationorfunction.
- Antiviral[10]andanti-angiogenic[6,7,8].
- Approvedtreatmentforexternalgenitalwartscausedbyhumanpapillomavirusinfection[10].
ProductReferences
- Imiquimodappliedtopically:anovelimmuneresponsemodifierandnewclassofdrug:R.L.Miller,etal.;Int.J.Immunopharmacol.21,1(1999)
- Areviewoftheapplicationsofimiquimod:anovelimmuneresponsemodifier:T.A.Syed,etal.;Exp.Opin.Pharmacother.2,877(2001)
- Smallanti-viralcompoundsactivateimmunecellsviatheTLR7MyD88-dependentsignalingpathway:H.Hemmi,etal.;Nat.Immunol.3,196(2002)
- Tumor-selectiveinductionofapoptosisandthesmall-moleculeimmuneresponsemodifierimiquimod:M.Schon,etal.;J.Natl.CancerInst.95,1138(2003)
- Molecularbasisfortheimmunostimulatoryactivityofguaninenucleosideanalogs:ActivationofToll-likereceptor7:J.Lee,etal.;PNAS100,6646(2003)
- Invivoandinsitumodulationoftheexpressionofgenesinvolvedinmetastasisandangiogenesisinapatienttreatedwithtopicalimiquimodformelanomaskinmetastases:C.Hesling,etal.;Br.J.Dermatol.150,761(2004)
- Imiquimodasanantiangiogenicagent:V.W.Li,etal.;J.DrugsDermatol.4,708(2005)
- Imiquimodisastronginhibitoroftumorcell-inducedangiogenesis:S.Majewski,etal.;Int.J.Dermatol.44,14(2005)
- Theantitumoralmodeofactionofimiquimodandotherimidazoquinolines:M.Schon&M.P.Schon;Curr.Med.Chem.14,681(2007)
- ThepharmacologyofendosomalTLRagonistsinviraldisease:D.R.Averett,etal.;Biochem.Soc.Trans.35,1468(2007)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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