脂肪原/IC87114/SYN-1045-M010/10毫克
商品编号：
SYN-1045-M010
品牌：
Adipogen Inc
市场价：
¥3460.00
美元价：
2076.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | IC-87114 |
| Product Type | Chemical |
| Properties | |
| Formula | C22H19N7O |
| MW | 397.4 |
| CAS | 371242-69-2 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. Slightly soluble (<1mg l)="" in="" ethanol.=""> |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: PI3K | Kinase Group: Lipid Kinase | Substrate: Lipid Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | GNWHRHGTIBRNSM-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
IC87114 is a potent, ATP-competitive, and selective inhibitor of PI3Kδ. IC(50) values (130-500nM) for IC87114 are sub-micromolar over a wide range of ATP concentrations from 10µM to 200µM. IC87114 can selectively inhibit cellular migration but not adhesion as well as cellular polarization. More recent work has shown the PIK3δ inhibition also plays a role in autoimmune disease suppression.
Product References
- Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement: C. Sadhu, et al.; J. Immunol. 170, 2647 (2003)
- The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors: A. Berndt, et al.; Nat. Chem. Biol. 6, 117 (2010)
- PI3Kdelta and PI3Kgamma as targets for autoimmune and inflammatory diseases: T.D. Cushing, et al.; J. Med. Chem. 55, 8559 (2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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